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Stent fracture is associated with in-stent restenosis (ISR), target lesion revascularization (TLR), stent thrombosis, myocardial infraction (MI) and major adverse cardiac event (MACE). However, the incidence of SF using Chinese domestic drug-eluting stent (DES) still remains unclear. In this study, 3411 patients with 5836 DESs and 1-year angiographic follow-up from 1007 patients who underwent percutaneous coronary intervention were studied. SF rate was 16.9% from patient level and 12.5% from stent level, with higher incidence in stainless stent platform (23.0% vs. 12.0% after cobalt-chromium stent, p<0.001), without difference between domestic and international DES. Most SFs were classified by Type I, whereas Type V SF is correlated with clinical events. Of 88 patients with 1-year TLR, repeat DES implantation was performed in 80 patients and balloon angioplasty was performed in the remaining 8 patients. After an 1523 (IQR) days (375∼3650 days) follow-up, repeat ISR was detected in 19 (23.8%) of patients, with 6 (7.5%) repeat TLR required. Of 19 repeat deployed DESs, SF occurred in 3 (3.8%) stents. In conclusion, SF is not rare after DES implantation. TLR was required in almost two third SF. Restenting using cobalt chromium DES was associated with acceptable clinical results.