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Ivabradine, a sinus node blocker, has been evaluated in multiple studies for heart rate reduction in computed tomography coronary angiography (CTCA). We aimed to performed a meta-analysis of studies comparing Ivabradine with Metoprolol for the same.
Pubmed, EBSCO and Cochrane databases were searched for terms “Ivabradine”, “Metoprolol”, “computed tomography coronary angiography” and their combinations. Only studies in English language and reporting data in usable format were included. Random effects model was used for heterogeneity. A ‘p’ value of <0.05 was considered significant. Review manager was used for statistical analysis.
A total of 4 studies with total 357 patients were included. Ivabradine was found to significantly decrease heart rate when compared to metoprolol (Mean difference -8.02, 95% CI -11.12 to -4.92, p <0.00001).
Ivabradine use was associated with significant reduction in heart rate when compared to metoprolol in use for computed tomography coronary angiography.