Author + information
- G. Andres Cortes,
- N. Irav Desai,
- Rad Nazila,
- David M. Shavelle,
- Anilkumar Mehra,
- Michael A. Gaglia,
- Ray V. Matthews and
- Leonardo Clavijo
Recent studies in large worldwide populations demonstrate that the metabolic syndrome (MS) increases the risk of acute myocardial infarction (AMI) without gender, ethnic or regional variations. The risk of AMI associated with MS appears no greater than the risk conferred by its individual components.
The goal of the study is to investigate the prevalence of metabolic syndrome in young patients with acute myocardial infarction (AMI) treated with percutaneous coronary intervention (PCI) and to compare the ATP III individual components of MS in young versus old patients.
A retrospective analysis of the University of Southern California interventional cardiology database was performed to identify patients with AMI (STEMI and NSTEMI, n=779) treated with PCI between January 2008 and June 2011. Two groups were generated according to the patient's age: young (≤45 years of age, n=81) and old (>45 years of age, n=698). Patients with MS were identified by the presence of at least 3 of the ATP III criteria and components of the MS were separately compared by age.
The MS was more prevalent in young patients with AMI (60.5% vs. 44.8%, p=0.02). Older patients were found to have higher rates of Hypertension (40.7% vs. 64.6%, p<0.001). Triglyceride levels were higher in younger patients (212mg/dl vs. 153.4mg/dl, p-value=0.014), while HDL levels (38.18mg/dl vs. 40.18mg/dl, p=0.22) and obesity rates (BMI < 30kg/m2, 25.92% vs. 26.5%, p=0.97) were similar between the groups. Single vessel CAD was more common in younger with MS patients (44.6% vs. 71.7%, p<0.001), as well as total occlusion of the infarct related artery (39.7% vs. 19.1%, p=0.0003).
The MS is highly prevalent in young patients with AMI. Younger patients compared to older patients with AMI treated with PCI have higher triglyceride levels, less hypertension, are more likely to have single vessel CAD and present with a totally occluded vessel.
- 2013 American College of Cardiology Foundation