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To define myocardial infarction in “young”, many studies taken < 40 to 45 yrs of age as cut off point. In young males with obstructive coronary artery disease we have data, but limited data in young females.
To see the disease pattern, risk factors, presentation, ventricular function and PCI efficiency of young females in comparison with young males with obstructive coronary artery disease who require PCI.
Material and Methods
We retrospectively analyzed the data of young patients (< 45 yrs of age) who undergone PCI over past two yrs. We noted the clinical, investigative and treatment modalities of these patients.
200 young patients undergone PCI for obstructive CAD with 42 females over two yr period. Females had more frequently hypertension (69.1% vs 43.7%) and Type 2 Diabetes (33.3% vs22.8%) which are statistically significant. Smoking was frequent in young males than young females. Males were presented as acute MI, where as females with rest chest pain. Multi-vessel involvement, LV dysfunction, success of PCI and complication rates were similar in both groups. Females are more anemic (< 11 g/dl in females and < 12g/dl in males). Complexicity of lesion (B2 or C type of lesions) is more in females which is statistically significant.
|No of patients||42||158|
|Hypertension||29 (69.1%)||69 (43.7%)||0.008|
|Diabetes||14 (33.3%)||36 (22.8%)||0.07|
|Smoking||02 (4.8%)||75 (47.5%)||0.00|
|Presentation(acs)||19 (45.2%)||99 (62.7%)||0.03|
|Presentation(mi)||8 (19.1%)||49 (31.1%)||0.03|
|LV dysfunction||10 (23.8%)||41 (25.9%)||0.3|
|Presence of anemia||10 (23.9%)||07 (4.4%)||0.0003|
|Multi vessel||8 (19.1%)||35 (22.2%)||ns|
|No of lesions per pt||1.3||1.3||ns|
|No of lesions||53||198|
|Complexitity of lesion (b2 or c)||36 (85.7%)||125 (79.1%)||0.02|
|Calcium at lesion||0||2 (1.3%)||ns|
|Toruosity of vessel||1 (2.4%)||5 (3.2%)||ns|
|site of lesion|
|Success of PCI||100%||98.42%||ns|
|No reflow||0||1 (0.63%)||ns|
|Acute or Subacute stent thrombosis||1 (2.3%)||2 (1.3%)||ns|
Young females had more frequently hypertension, Diabetes, acute coronary syndrome without MI, mild anemia, complex lesions than young males, but with same success and complication rate of PCI.
- 2013 American College of Cardiology Foundation