Author + information
- Received June 27, 2008
- Revision received October 14, 2008
- Accepted November 7, 2008
- Published online February 1, 2009.
- Han S. Lim, MBBS⁎,⁎⁎,
- Omar Farouque, MBBS, FRACP, PhD, FACC⁎,†,
- Nick Andrianopoulos, MBBS, MBiostat‡,
- Bryan P. Yan, MBBS, FRACP§,††,
- Chris C.S. Lim, MBBS∥,
- Angela L. Brennan, RN, CCRN‡,
- Chris M. Reid, BA, MSc, DipEd, PhD‡,
- Melanie Freeman, MBBS⁎,
- Kerrie Charter, RN, CCRN⁎,
- Alexander Black, MBBS, FRACP†,§,¶,
- Gishel New, MBBS, FRACP, PhD, FACC∥,
- Andrew E. Ajani, MBBS, FRACP, FJFICM, MD†,‡,§,
- Stephen J. Duffy, MBBS, MRCP, FRACP, PhD#,
- David J. Clark, MBBS, FRACP⁎,⁎ (, )
- Melbourne Interventional Group
- ↵⁎Reprint requests and correspondence:
Dr. David J. Clark, Austin Health, Cardiology, PO Box 5555, 145 Studley Road, Heidelberg, Melbourne, Victoria 3084, Australia
Objectives We sought to assess clinical outcomes of elderly patients (age ≥75 years) undergoing percutaneous coronary intervention (PCI) for acute myocardial infarction (MI) complicated by cardiogenic shock (CS) in a contemporary multicenter PCI registry.
Background Although benefits of early PCI have been shown in younger groups, few studies have reported on clinical outcomes in elderly shock patients using current PCI techniques.
Methods We analyzed baseline characteristics and procedural and clinical outcomes in 143 consecutive patients presenting with MI and CS who underwent PCI from the Melbourne Interventional Group registry between 2004 and 2007.
Results Of the 143 patients, 31.5% (n = 45) were elderly and 68.5% were younger (age <75 years). Elderly patients were more likely to be female (46.7% vs. 22.4%, p < 0.01) and have hypertension (77.8% vs. 46.4%, p < 0.01), previous MI (31.1% vs. 15.5%, p = 0.03), renal failure (24.4% vs. 11.3%, p < 0.05) and multivessel coronary artery disease (93.1% vs. 68.3%, p < 0.01). Stent (86.7% vs. 94.8%, p = 0.09), glycoprotein IIb/IIIa inhibitor (68.9% vs. 65.3%, p = 0.67), and intra-aortic balloon pump (57.8% vs. 58.2%, p = 0.97) use were similar in both groups. In-hospital, 30-day, and 1-year mortality in the elderly group versus the younger group were 42.2% vs. 33.7% (p = 0.32), 43.2% vs. 36.1% (p = 0.42), and 52.6% vs. 46.8% (p = 0.56), respectively.
Conclusions In this study, the 1-year survival of elderly patients with acute MI complicated by CS undergoing PCI was comparable to younger patients. These data suggest that in elderly patients presenting with CS, benefit is possible with selective use of early revascularization and merits further investigation.
The Melbourne Interventional Group acknowledges funding from Abbott Vascular, AstraZeneca, Biotronik, Boston Scientific, Johnson & Johnson, Medtronic, Pfizer, Schering-Plough, Sanofi-Aventis, Servier, St. Jude Medical, and Terumo. These companies do not have access to the data, and do not have the right to review articles before publication. Dr. Duffy's work is supported by a National Health and Medical Research Council of Australia Program Grant.
- Received June 27, 2008.
- Revision received October 14, 2008.
- Accepted November 7, 2008.
- American College of Cardiology Foundation