Author + information
- Ting-Yu Wang,
- Luis Gruberg,
- Smadar Kort,
- Javed Butler,
- Allen Jeremias,
- Joanna Chikwe and
- Puja B. Parikh
Limited data exists regarding gender differences in outcomes following transcatheter (TAVR) and surgical aortic valve replacement (SAVR). We sought to review the published data and perform a systematic review to investigate differences in mortality between men and women following TAVR and SAVR.
We systematically searched Medline from 1972 to May 2017 for randomized trials and observational studies examining the relationship between gender and mortality outcomes in patients following TAVR or SAVR. Two authors selected studies and extracted data independently. Studies were excluded if data regarding 30-day all-cause mortality were not provided for both men and women.
There were 34 articles, a total of 41,089 patients, enrolled in our systematic review and meta-analysis, including 22,894 men and 18,195 women. Of these 34 articles, 19 involved TAVR, 13 involved SAVR, and 2 involved both TAVR and SAVR. Rates of 30-day all-cause mortality following TAVR was noted to be similar in men and women [odds ratio (OR) 0.99, 95% confidence interval (CI), 0.87 to 1.11]. Men had lower rates of 30-day all-cause mortality following SAVR compared to women (OR 0.72, 95% CI, 0.62 to 0.83) (Figure).
Female gender is associated with higher rates of mortality following SAVR. No significant differences in mortality were noted in men versus women following TAVR.