Author + information
Cancer is a major cause of mortality. However, the morbidity and mortality related to cancer in patients undergoing percutaneous coronary intervention (PCI) have not been the focus of studies.
The aim of this study is to clarify the relationship between prior cancer and mortality in patients undergoing PCI.
This retrospective study involved 2254 consecutive patients undergoing PCI. In this population, 216 patients with prior cancer and 861 emergent PCI cases were included. Mortality of patients with prior cancer was compared with those without prior cancer. Mean follow-up period was 1426 +/- 832 days.
Patients with prior cancer included 75 (34.7%) emergent PCI, which was comparable with those without prior cancer (38.6%, p=NS.). Patients with prior cancer had higher mortality (14.4% vs. 7.2%, p=0.001). However, cardiovascular mortality was not significantly different between patients with prior cancer and those without prior cancer (3.7% vs. 4.7% p=NS.). Kaplan-Meier analysis (Figure) revealed that patients with prior cancer experienced higher mortality than those without prior cancer. There was no significant difference of cardiovascular mortality between cancer and non-cancer group, although patients with prior cancer experienced higher cancer mortality. Even in the emergent PCI patients, comparable results were obtained. Multivariate Cox proportional hazard analysis showed that prior cancer was an independent predictor of mortality (HR 2.10 [1.38 - 3.18], p=0.0005).
In conclusion, patients with prior cancer had higher mortality than those without prior cancer. It depends on cancer mortality, even in patients undergoing emergent PCI.