Table 4

1-Year Major Clinical Outcomes

Overall (n = 5,054)Standard-Risk (n = 1,827)Extended-Risk (n = 3,227)SPIRIT IV EECSS (n = 2,458)p Value
Death131 (2.6%)34 (1.8%)97 (3.1%)25 (1.0%)0.03
Cardiac death80 (1.6%)17 (0.9%)63 (2.0%)10 (0.4%)0.05
MI (ARC)268 (5.4%)59 (3.2%)209 (6.7%)
Q-wave31 (0.6%)5 (0.3%)26 (0.8%)
Non–Q-wave242 (4.9%)54 (2.9%)188 (6.0%)
MI (WHO)102 (2.1%)20 (1.1%)82 (2.6%)45 (1.9%)0.04
Q-wave31 (0.6%)5 (0.3%)26 (0.8%)3 (0.1%)0.30
Non–Q-wave73 (1.5%)15 (0.8%)58 (1.9%)42 (1.7%)0.01
Cardiac death/MI (ARC)320 (6.5%)70 (3.8%)250 (8.0%)
Cardiac death/MI (WHO)166 (3.3%)35 (1.9%)131 (4.2%)54 (2.2%)0.52
TLF (cardiac death/TVMI [ARC]/CI-TLR)416 (8.4%)86 (4.7%)330 (10.6%)
TLF (cardiac death/TVMI [WHO]/CI-TLR)330 (6.7%)65 (3.5%)2,653 (8.5%)101 (4.2%)0.30
All death/MI (ARC)/ revascularization)682 (13.8%)184 (10.0%)498 (16.0%)
All death/MI (WHO)/ revascularization)598 (12.1%)161 (8.8%)437 (14.0%)218 (9.0%)0.79
TLR221 (4.5%)41 (2.2%)180 (5.8%)66 (2.7%)0.32
TVR, non-TLR109 (2.2%)40 (2.2%)69 (2.2%)57 (2.4%)0.76
TIMI major bleeding123 (2.5%)37 (2.0%)86 (2.8%)

Values are n (%).

CI = clinically indicated; MI = myocardial infarction; TIMI = Thrombolysis In Myocardial Infarction; TLF = target lesion failure; TLR = target lesion revascularization; TVMI = myocardial infarction attributed to target vessel; TVR = target vessel revascularization; WHO = World Health Organization; other abbreviations as in Table 3.

  • Standard-risk versus the SPIRIT IV trial.