Table 3

High-Risk PCI

Clinical
 LVEF <35%
 Electrical instability
 Congestive heart failure
Comorbidities
 Severe aortic stenosis
 Severe mitral regurgitation
 Chronic obstructive pulmonary disease
 Chronic kidney disease
 Diabetes
 Cerebrovascular disease
 Peripheral vascular disease
 Age >75 yrs
 Acute coronary syndrome
Coronary anatomy
 Last patent vessel
 UPLMN
 3 vessel disease, SYNTAX score >33
 Target vessel providing collaterals to a territory, which supplies >40% of the myocardium
 Distal left main bifurcation

High-risk percutaneous coronary intervention (PCI) is defined in multiple clinical trials according to several key clinical features, comorbidities, and anatomical features that have shown to cause increased morbidity and mortality during PCI Adapted with permission from Myat et al. (43).

LVEF = left ventricular ejection fraction; UPLMN = unprotected left main coronary artery.