Table 3

Periprocedural and Follow-up Medication

Clopidogrel+
Prasugrel
(n = 427)
Prasugrel
(n = 447)
p Value
Medication during primary PCI
 Unfractionated heparin409 (95.8)360 (80.7)<0.001
 Bivalirudin51 (11.9)105 (23.5)<0.001
 GP IIb/IIIa antagonist124 (29.0)178 (39.9)0.001
Loading doses, mg<0.001
 Clopidogrel alone1 (0.2)0 (0.0)
  30038 (9.0)
  600380 (89.6)
  Other3 (0.7)
  N/A3 (0.7)
 Prasugrel alone3 (0.7)430 (96.2)<0.001
  3046 (10.8)6 (1.4)<0.001
  60370 (86.9)435 (97.3)<0.001
  Other8 (1.9)3 (0.7)0.14
  N/A2 (0.5)3 (0.7)1.00
 Both clopidogrel and prasugrel424 (99.1)0 (0.0)<0.001
 1 week double clopidogrel dose1 (0.2)0 (0)N/A
At discharge
 Aspirin423 (99.5)440 (99.5)1.00
 Prasugrel408 (96.0)393 (88.9)<0.001
 Clopidogrel16 (3.8)39 (8.8)0.003
 Any DAPT422 (99.3)433 (98.0)0.14
At 30 days
 Aspirin414 (99.0)432 (99.3)0.72
 Prasugrel384 (91.9)376 (86.4)0.01
 Clopidogrel38 (9.1)49 (11.3)0.31
 Any DAPT413 (98.8)420 (96.6)0.04
At 1 year
 Aspirin392 (98)412 (96.5)0.209
 Prasugrel327 (81.8)333 (78.0)0.19
 Clopidogrel42 (10.5)47 (11.0)0.82
 Any DAPT362 (90.5)376 (88.1)0.26
High-risk patients (age ≥75 yrs or weight <60 kg, or history of stroke/TIA)§n = 53n = 40
 Clopidogrel loading dose, mgn = 52
  3002 (3.8)
  60048 (92.3)
  Other1 (1.9)
  N/A1 (1.9)
 Prasugrel loading dose, mgn = 53n = 380.680
  301 (1.9)0 (0.0)1.000
  6050 (94.3)37 (97.4)0.638
  Other1 (1.9)0 (0.0)1.000
  N/A1 (1.9)1 (2.6)1.000

Values are n (%).

Patients grouped according to the loading dose, already on daily maintenance dose MD, or immediate post-procedure exposure.

DAPT = dual antiplatelet therapy; GP = glycoprotein; N/A = not available; PCI = percutaneous coronary intervention; TIA = transient ischemic attack.

  • p values (prasugrel + clopidogrel vs. prasugrel alone) from chi-square or Fisher exact test.

  • Already on maintenance dose of prasugrel.

  • Already on maintenance dose of clopidogrel. Number of patients who received loading dose of prasugrel or clopidogrel. Excludes patients without any loading.

  • § Excludes 19 patients with the weight missing, but all 19 were assumed low risk because all 19 were younger than 75 years of age and did not have a history of stroke.