Table 1

Baseline Characteristics

MT
(n = 44)
SAVR
(n = 52)
TAVR
(n = 108)
p Value
Age, yrs82.7 ± 4.778.4 ± 4.182.5 ± 4.4<0.001
Female18 (41)19 (37)45 (42)0.82
Height, cm166.9 ± 8.2167.1 ± 8.9165.3 ± 8.00.35
Weight, kg68.2 ± 11.274.0 ± 15.369.6 ± 14.40.09
Body mass index, kg/m224.6 ± 3.226.4 ± 4.625.4 ± 4.80.13
Body surface area, m21.8 ± 0.21.8 ± 0.21.8 ± 0.20.15
Cardiac risk factors
 Diabetes mellitus13 (30)17 (33)35 (32)0.93
 Hypercholesterolemia25 (57)32 (62)72 (67)0.50
 Hypertension31 (70)43 (83)87 (81)0.29
 Current smoker5 (11%)23 (44%)12 (11%)<0.001
Medical history
 Previous stroke9 (20)7 (13)9 (8)0.11
 Peripheral vascular disease11 (25)6 (12)29 (27)0.09
 Chronic obstructive pulmonary disease10 (23)7 (13)17 (16)0.45
 Renal failure (GFR <50 ml/min/1.73 m2)31 (74)20 (38)36 (33)<0.001
 Previous permanent pacemaker5 (11)9 (17)13 (12)0.60
Coronary artery disease
 SYNTAX score22.3 ± 19.314.0 ± 14.116.1 ± 15.50.06
 Coronary artery disease32 (73)40 (77)80 (74)0.89
 Previous MI15 (34)13 (25)27 (25)0.49
 Previous CABG15 (34)0 (0)27 (25)<0.001
 Previous PCI9 (20)4 (8)42 (39)<0.001
Baseline cardiac rhythm
 Atrial fibrillation22 (50)17 (33)30 (28)0.04
Symptoms
 NYHA functional class III/IV29 (66)35 (67)85 (82)0.05
 CCS angina status III/IV7 (16)13 (25)16 (15)0.27
Risk assessment
 Logistic EuroSCORE, %41.2 ± 16.018.7 ± 13.034.5 ± 15.3<0.001
 STS score, %11.2 ± 7.34.9 ± 2.97.9 ± 4.9<0.001
 STS score, %9.8 (5.9–15.8)4.2 (3.2–5.5)6.6 (4.6–9.9)<0.001
Medications
 Aspirin21 (48)40 (77)72 (67)0.01
 Clopidogrel8 (18)2 (4)29 (27)0.00
 Oral anticoagulation18 (41)11 (21)34 (31)0.11

Values are mean ± SD with p values from analyses of variance or n (%) with p values from chi-square tests. STS score was left-skewed, and therefore also median (25% to 75% interquartile range) with Kruskal-Wallis and Mann-Whitney U tests is reported.

CABG = coronary artery bypass grafting; CCS = Canadian Cardiovascular Society; GFR = glomerular filtration rate; MI = myocardial infarction; MT = medical therapy; NYHA = New York Heart Association; PCI = percutaneous coronary intervention; SAVR = surgical aortic valve replacement; STS = Society of Thoracic Surgeons; TAVR = transcatheter aortic valve replacement.

  • Sample sizes for SYNTAX score: 33, 48, 106; renal failure, n = 2 missing for medical therapy; chronic obstructive pulmonary disease, n = 1 missing for transcatheter aortic valve replacement; atrial fibrillation; n = 2 missing for transcatheter aortic valve replacement.