Table 1

Baseline Characteristics and Clinical Presentation

Quintile 1
PRU <95
(n = 1,690)
Quintile 2
PRU 95–159
(n = 1,669)
Quintile 3
PRU 160–215
(n = 1,691)
Quintile 4
PRU 216–275
(n = 1,706)
Quintile 5
PRU >275
(n = 1,692)
p Value
Age, yrs62.2 ± 10.863.2 ± 10.763.1 ± 10.864.2 ± 10.865.3 ± 10.8<0.001
Male1,332 (78.8)1,313 (78.7)1,314 (77.7)1,260 (73.9)1,066 (63.0)<0.001
Body mass index, kg/m227.8 ± 4.728.8 ± 5.029.5 ± 5.630.2 ± 6.030.9 ± 6.5<0.001
Diabetes mellitus355 (21.0)426 (25.5)527 (31.2)644 (37.8)774 (45.7)<0.001
 Insulin-treated124 (7.3)133 (8.0)186 (11.0)234 (13.7)302 (17.9)<0.001
History of peripheral arterial disease178 (10.5)157 (9.4)151 (8.9)176 (10.3)199 (11.8)0.065
History of congestive heart failure119 (7.0)112 (6.7)126 (7.5)145 (8.5)185 (10.9)<0.001
Previous myocardial infarction433 (25.6)408 (24.5)427 (25.3)424 (24.9)436 (25.8)0.90
Previous coronary artery bypass graft surgery270 (16.0)254 (15.2)307 (18.2)289 (16.9)318 (18.8)0.03
Previous percutaneous coronary intervention784 (46.4)704 (42.2)697 (41.2)724 (42.4)710 (42.0)0.02
History of renal insufficiency110 (6.5)91 (5.5)115 (6.8)136 (8.0)195 (11.5)<0.001
 History of dialysis14 (0.8)26 (1.6)22 (1.3)29 (1.7)42 (2.5)0.003
Hypertension1,330 (78.7)1,286 (77.1)1,332 (78.8)1,381 (81.0)1,397 (82.6)0.001
Hyperlipidemia1,284 (76.0)1,212 (72.6)1,233 (72.9)1,278 (74.9)1,282 (75.8)0.07
Cigarette smoking, current471 (27.9)408 (24.5)382 (22.6)378 (22.2)285 (16.8)<0.001
Presenting clinical syndrome
 Acute coronary syndrome796 (47.1)821 (49.2)865 (51.2)925 (54.2)938 (55.4)<0.001
  Unstable angina458 (27.1)456 (27.3)453 (26.8)470 (27.6)475 (28.1)0.94
  Non-ST-segment elevation234 (13.9)211 (12.6)242 (14.3)266 (15.6)271 (16.0)0.04
  ST-segment elevation104 (6.2)154 (9.2)170 (10.1)189 (11.1)192 (11.4)<0.001
 Stable angina565 (33.4)525 (31.5)485 (28.7)464 (27.2)429 (25.4)<0.001
Baseline laboratory parameters
 Hemoglobin, g/dl14.4 ± 1.514.3 ± 1.514.2 ± 1.513.9 ± 1.413.1 ± 1.4<0.001
 Creatinine clearance, ml/min/1.73 m292.0 ± 33.095.6 ± 34.896.7 ± 38.595.3 ± 39.191.2 ± 40.4<0.001
 White blood cell count, ×106/ml8.0 ± 3.57.9 ± 4.07.9 ± 2.98.1 ± 2.97.9 ± 2.60.61
 Platelet count, ×106/mm3234.9 ± 67.1222.4 ± 62.6224.4 ± 59.8224.5 ± 61.8226.8 ± 62.3<0.001

Values are mean ± SD or n (%).

PRU = P2Y12 reaction units.