Table 1

Sympathetic Nerve Conduction Velocity, Axon Diameter, and Myelin Thickness in Animals With and Without mPAP >25 mm Hg

nSNCV (m/s)Axon Diameter (μm)Myelin Thickness (μm)
Normal animals614.15 ± 2.302.15 ± 0.280.37 ± 0.01
mPAP ≤25 mm Hg1040.33 ± 5.085.27 ± 0.41†1.13 ± 0.03
mPAP >25 mm Hg25
 Prior to PADN548.07 ± 4.77‡5.98 ± 0.20‡1.62 ± 0.05‡
 After PADN20
  Post-PADN537.99 ± 3.33§4.75 ± 0.48§0.87 ± 0.06§
  1 month526.34 ± 4.94‖3.53 ± 0.29¶0.62 ± 0.05¶
  2 months517.82 ± 4.85¶3.51 ± 0.33¶0.55 ± 0.06¶
  3 months513.05 ± 3.763.13 ± 0.190.39 ± 0.05

Values are mean ± SD.

mPAP = mean pulmonary arterial pressure; PADN = pulmonary artery denervation; SNCV = sympathetic nerve conduction velocity.

  • p < 0.001, compared with all groups; †p < 0.01, compared with prior to PADN group and normal animals; ‡p < 0.001, compared with all subgroups in after PADN group; §p < 0.001, compared with 1, 2, and 3 months groups; ‖p < 0.01, compared with mPAP ≤25 mm Hg, 2 months, and 3 months groups; ¶p < 0.05, compared with the 3 months group.