Table 5

Major Bleeds Beyond 6 Months Post-Randomization According to Subgroup

LAA ClosureWarfarinHazard Ratio (95% Confidence Interval)p Valuep Interaction
Age ≤75 yrs1.4 (6/436)7.8 (17/217)0.17 (0.147–0.196)<0.0010.005
Age >75 yrs4.4 (13/296)10.9 (18/165)0.43 (0.264–0.701)0.001
CHA2DS2-VASc ≤41.8 (10/551)8.5 (22/258)0.21 (0.138–0.321)<0.0010.28
CHA2DS2-VASc >45.1 (9/178)10.7 (13/121)0.47 (0.161–1.378)0.17
Modified HAS-BLED <31.4 (8/561)7.9 (23/291)0.17 (0.173–0.174)<0.0010.001
Modified HAS-BLED ≥36.4 (11/171)13.2 (12/91)0.55 (0.282–1.070)0.078
No history of TIA/stroke2.3 (13/570)8.9 (26/292)0.26 (0.216–0.305)<0.0010.67
History of TIA/stroke3.7 (6/162)10.0 (9/90)0.35 (0.102–1.225)0.10
Female1.8 (4/224)12.0 (13/108)0.17 (0.074–0.369)<0.0010.02
Male3.0 (15/508)8.0 (22/274)0.35 (0.320–0.393)<0.001

Values are % (n/N) unless otherwise specified.

LAA = left atrial appendage; TIA = transient ischemic attack.