Table 4

Multivariable Cox Regression Models of PRU Quintiles With Clinical Outcomes

Hazard Ratio95% Confidence Intervalp Value
Stent thrombosis, definite or probable
 PRU Q1, referent1.00
 PRU Q2 vs. Q11.130.51–2.480.76
 PRU Q3 vs. Q11.370.64–2.900.41
 PRU Q4 vs. Q11.710.84–3.490.14
 PRU Q5 vs. Q12.321.17–4.590.02
Clinically relevant bleeding
 PRU Q1, referent1.00
 PRU Q2 vs. Q10.740.60–0.930.010
 PRU Q3 vs. Q10.710.57–0.890.003
 PRU Q4 vs. Q10.630.50–0.79<0.001
 PRU Q5 vs. Q10.610.47–0.77<0.001
All-cause mortality
 PRU Q1, referent1.00
 PRU Q2 vs. Q10.900.58–1.400.64
 PRU Q3 vs. Q11.220.82–1.840.33
 PRU Q4 vs. Q11.170.78–1.730.45
 PRU Q5 vs. Q11.080.72–1.600.72

MI = myocardial infarction; PR = platelet reactivity; PRU = P2Y12 reaction units; Q = quintile(s).

  • Model includes PR quintile, clopidogrel usage (time dependent), insulin treatment, previous MI, history of dialysis, ST-segment elevation MI, baseline white blood cell count, baseline platelet count.

  • Model includes PR quintile, clopidogrel usage (time dependent), age, history of renal insufficiency, history of hypertension, current smoking status, number of vessels treated per patient, baseline hemoglobin, baseline white blood cell count.

  • Model includes PR quintile, clopidogrel usage (time dependent), age, male sex, history of diabetes, previous MI, history of renal insufficiency, current smoking status, ST-segment elevation MI, non–ST-segment elevation MI, baseline hemoglobin, creatinine clearance, white blood cell count.