Table 3

Clinical Outcomes at 2 Years

Quintile 1
PRU <95
(n = 1,690)
Quintile 2
PRU 95–159
(n = 1,669)
Quintile 3
PRU 160–215
(n = 1,691)
Quintile 4
PRU 216–275
(n = 1,706)
Quintile 5
PRU >275
(n = 1,692)
p Value
Death, all-cause47 (2.9)47 (2.9)62 (3.9)69 (4.3)81 (5.0)0.006
 Cardiovascular29 (1.8)27 (1.7)39 (2.5)41 (2.6)53 (3.3)0.02
 Noncardiovascular18 (1.1)20 (1.3)23 (1.5)28 (1.7)28 (1.8)0.46
Myocardial infarction69 (4.3)59 (3.7)70 (4.3)79 (4.9)106 (6.5)0.001
 Q-wave9 (0.6)5 (0.3)7 (0.4)13 (0.8)19 (1.2)0.02
 Non–Q-wave60 (3.7)54 (3.4)66 (4.1)67 (4.1)88 (5.4)0.04
Target vessel failure239 (14.7)202 (12.6)256 (15.7)270 (16.5)284 (17.5)0.001
Stent thrombosis
 Definite or probable12 (0.7)13 (0.8)16 (1.0)21 (1.3)29 (1.8)0.025
 Definite9 (0.6)10 (0.6)13 (0.8)17 (1.0)23 (1.4)0.055
Clinically relevant bleeding182 (11.2)134 (8.3)133 (8.1)129 (8.0)143 (9.1)0.006
 In-hospital bleeding76 (4.5)49 (2.9)47 (2.8)46 (2.7)41 (2.4)0.004
 Out-of-hospital bleeding144 (8.9)114 (7.1)110 (6.8)101 (6.3)127 (8.1)0.03

Values are n (%).

PRU = P2Y12 reaction units.