Table 2

Changes in the Hemodynamics and PA Remodeling in the 3 Groups

Control (n = 10)PADN (n = 9)Sham (n = 7)
Heart, beats/min
 Week 0148 ± 25147 ± 15150 ± 17
 Week 8139 ± 23159 ± 21159 ± 22
 Week 14134 ± 27†160 ± 22159 ± 24
RAP, mm Hg
 Week 01.7 ± 0.91.9 ± 1.31.7 ± 0.9
 Week 82.0 ± 1.0‡2.7 ± 2.5§2.7 ± 1.2
 Week 141.9 ± 0.9†2.3 ± 0.8‖3.2 ± 0.9
RVSP, mm Hg
 Week 032.0 ± 3.732.7 ± 7.132.4 ± 7.0
 Week 833.4 ± 3.4†49.0 ± 4.0§49.1 ± 6.8
 Week 1436.0 ± 4.3†44.9 ± 6.9‖55.8 ± 5.7
sPAP, mm Hg
 Week 027.9 ± 2.227.6 ± 5.327.3 ± 3.8
 Week 829.9 ± 2.3†46.3 ± 4.3§45.2 ± 5.5
 Week 1432.2 ± 3.0†40.6 ± 4.6‖52.1 ± 6.6
mPAP, mm Hg
 Week 015.3 ± 2.215.3 ± 3.014.4 ± 3.6
 Week 816.9 ± 1.7†27.7 ± 1.9§28.6 ± 2.2
 Week 1417.3 ± 2.8†23.5 ± 2.3‖33.7 ± 5.8
Cardiac output, l/min
 Week 03.6 ± 0.53.5 ± 0.63.5 ± 0.5
 Week 83.4 ± 0.72.5 ± 0.72.5 ± 0.9
 Week 143.3 ± 0.8†2.9 ± 0.8‖2.0 ± 0.6
PVR, Wood units
 Week 02.6 ± 0.52.6 ± 0.92.7 ± 0.5
 Week 82.9 ± 0.5†5.9 ± 0.6¶6.2 ± 0.6
 Week 143.1 ± 0.5†3.5 ± 0.7#7.7 ± 0.7
MWT at week 14, %11.8 ± 1.2‖22.3 ± 3.3‖30.4 ± 4.1
Muscularization at week 14, mean ± SD of %
 None59.1 ± 9.7†29.8 ± 6.1‖12.9 ± 4.9
 Partial29.4 ± 9.829.8 ± 9.730.3 ± 3.7
 Fully11.5 ± 2.6†40.3 ± 9.3‖57.1 ± 5.7

Values are mean ± SD.

mPAP = mean pulmonary arterial pressure; MWT = medial wall thickness; PA = pulmonary artery; PVR = pulmonary vessel resistance; RAP = right atrial pressure; RVSP = right ventricular systolic pressure; sPAP = systolic pulmonary arterial pressure.

  • p = 0.005 compared with the PADN and sham groups; †p < 0.001 compared with the PADN and sham groups; ‡p = 0.008 compared with the PADN and sham groups; §p < 0.05 compared with value measured at week 14; ‖p < 0.001 compared with the sham group; ¶p < 0.01 compared with value at week 14; #p = 0.005 compared with the sham group.