Table 2

Echocardiographic and Hemodynamic Measurements

Sildenafil GroupPADN Groupp Value
Baseline (n = 50)6-Month (n = 45)p ValueBaseline (n = 48)6-Month (n = 46)p Value
Echocardiographic measurements
 Systolic PAP, mm Hg57.7 ± 7.758.3 ± 7.00.54658.3 ± 7.952.2 ± 7.5<0.0010.017
 Pericardial effusion, mm2.1 (0–13)2.2 (0–15)0.6681.9 (0–12)0.96 (0–7)0.0120.010
 LA diameter, mm53.1 ± 9.355.4 ± 9.80.10752.6 ± 9.250.5 ± 9.60.1030.004
 LVDd, mm59.8 ± 12.360.7 ± 12.30.21358.4 ± 13.157.1 ± 13.00.2910.019
 LV Tei index, %0.59 ± 0.090.58 ± 0.090.4410.61 ± 0.100.49 ± 0.070.0090.036
 LV ejection fraction, %44.5 ± 16.542.3 ± 15.70.10243.2 ± 15.447.9 ± 14.30.0550.050
  % of increase−4.8+10.40.031
 E/E′ ratio17.66 ± 6.8117.88 ± 6.040.87318.04 ± 7.2510.58 ± 3.170.0100.011
 TAPSE, mm15.3 ± 4.915.1 ± 2.70.80215.8 ± 3.619.7 ± 2.80.0220.017
 RV Tei index, %0.44 ± 0.120.45 ± 0.100.5030.49 ± 0.170.38 ± 0.110.0140.016
 RA long-axis diameter, mm60.4 ± 12.459.6 ± 10.70.65759.7 ± 13.558.2 ± 11.10.6640.561
 RA short-axis diameter, mm48.6 ± 11.546.9 ± 12.70.23448.7 ± 10.446.9 ± 10.20.1280.986
Hemodynamic measurements via right heart catheterization
 RA pressure, mm Hg13.8 ± 5.613.1 ± 4.10.32213.8 ± 7.311.0 ± 5.10.1220.189
 Systolic PAP, mm Hg56.5 ± 15.252.4 ± 11.30.19658.7 ± 19.544.6 ± 19.2<0.001<0.001
 Mean PAP, mm Hg36.9 ± 10.834.4 ± 7.90.13338.8 ± 10.628.6 ± 6.5<0.0010.037
 Cardiac output, l/min2.56 ± 0.742.51 ± 0.720.5642.61 ± 0.763.09 ± 0.810.0210.017
 Cardiac index, l/min/m21.67 ± 0.791.72 ± 0.640.0891.72 ± 0.842.52 ± 0.700.0380.035
 PVR, Woods units6.25 ± 3.236.09 ± 2.940.5906.38 ± 3.194.18 ± 1.51<0.0010.001
 PCWP, mm Hg20.9 ± 5.5819.1 ± 6.10.90922.2 ± 6.616.1 ± 6.20.0130.041
 TPG, mm Hg16.1 ± 4.615.3 ± 3.80.10116.5 ± 4.712.9 ± 3.90.0010.002
  >12 mm Hg29 (58.0)25 (55.6)0.53035 (73.0)17 (38.6)0.0010.047
 DPG, mm Hg10.4 ± 3.29.86 ± 1.740.12010.9 ± 3.76.8 ± 1.20.0110.042
 PAC, ml/mm Hg1.96 ± 0.651.95 ± 0.860.9441.92 ± 0.863.9 ± 0.96<0.001<0.001

Values are mean ± SD, median (interquartile range), or n (%).

DPG = diastolic pressure gradient; LA = left atrial; LV = left ventricle; LVDd = left ventricular end-systolic diameter; PAC = pulmonary arterial compliance; PAP = pulmonary arterial pressure; PCWP = pulmonary capillary wedge pressure; RA = right atrial; RV = right ventricle; RVP = right ventricular pressure; TAPSE = tricuspid annual plane systolic excursion; TPG = transpulmonary pressure gradient; VTI = velocity time integral; other abbreviations as in Table 1.

  • Indicates a comparison between two 6-month subgroups.