Table 2

Baseline Characteristics of Combined S3HR and S3i Cohorts

Women (n = 657)Men (n = 1,004)p Value
Age, yrs82.5 ± 7.282.0 ± 7.10.20
STS-PROM score, %6.8 ± 3.06.3 ± 2.80.003
Mean EuroSCORE5.5 ± 4.77.2 ± 6.3<0.0001
Body surface area, m21.8 ± 0.22.0 ± 0.2<0.0001
Frail, %145 (22.1)127 (12.6)<0.0001
Diabetes type II, %205 (31.2)353 (35.2)0.10
Hyperlipidemia, %498 (75.8)834 (83.1)0.0003
Hypertension, %609 (92.7)935 (93.1)0.74
Smoking, %238 (36.2)621 (61.9)<0.0001
O2 dependent chronic obstructive pulmonary disease, %57 (8.7)57 (6.5)0.003
Severe pulmonary hypertension, %18 (2.7)37 (3.7)0.29
Renal insufficiency, %43 (6.5)109 (10.9)0.003
Coronary artery disease, %387 (58.9)808 (80.5)<0.0001
Prior myocardial infarction, %69 (10.5)220 (21.9)<0.0001
Prior percutaneous coronary intervention, %162 (24.7)383 (38.0)<0.0001
Prior coronary artery bypass grafting, %65 (9.9)429 (42.7)<0.0001
Cerebrovascular disease, %108 (16.4)185 (18.4)0.30
Peripheral vascular disease, %141 (21.5)368 (36.7)<0.0001
Cardiomyopathy, %35 (5.3)108 (10.8)0.0001
Permanent pacemaker, %73 (11.1)165 (16.4)0.002
Mean echocardiographic findings
 Aortic valve area, cm20.64 ± 0.160.72 ± 0.17<0.0001
 Aortic valve index, cm2/m20.37 ± 0.090.36 ± 0.080.12
 Aortic valve mean gradient, mm Hg47.8 ± 13.844.6 ± 12.8<0.0001
 Annular dimension, cm2.1 ± 0.22.3 ± 0.2<0.0001
 Left ventricular ejection fraction0.62 ± 0.120.55 ± 0.14<0.0001
 Stroke volume (Teichholz), ml/beat60.7 ± 17.266.5 ± 19.0<0.0001

Values are mean ± SD or n (%).

EuroSCORE = European System for Cardiac Operative Risk Evaluation; STS-PROM = Society of Thoracic Surgeons Predicted Risk of Mortality; other abbreviations as in Table 1.

  • Creatinine level ≥2.0 mg/dl.