Table 1

Patient and Vessel Characteristics

Total
(N = 94)
Preserved FFR/CFR
(n = 56)
Low FFR/CFR
(n = 8)
Preserved FFR/Low CFR
(n = 25)
Low FFR/Preserved CFR
(n = 5)
p Value
Age (yrs)56 ± 1156 ± 1257 ± 953 ± 1159 ± 50.673
Male47 (50)26 (46)7 (88)10 (40)4 (80)0.054
African-American race29 (31)16 (29)2 (22)8 (33)3 (60)0.1
Body mass index (kg/m2)30 ± 730 ± 732 ± 631 ± 728 ± 40.711
Cardiovascular risk factors
 Hypertension69 (73)40 (71)4 (50)21 (84)4 (80)0.269
 Diabetes mellitus22 (23)11 (20)1 (13)5 (20)4 (80)0.032
 Dyslipidemia52 (55)27 (54)2 (25)19 (76)2 (40)0.027
 Current smoker19 (20)9 (16)2 (25)5 (20)3 (60)0.126
 Prior myocardial infarction11 (12)4 (7)05 (20)2 (40)0.057
 Prior PCI20 (21)9 (16)2 (25)6 (24)2 (40)0.455
 Family history of premature CAD45 (48)30 (54)4 (50)8 (32)1 (20)0.209
Vital signs
 SBP (mm Hg)134 ± 20137 ± 21124 ± 17130 ± 16133 ± 250.288
 DBP (mm Hg)75 ± 1177 ± 1373 ± 674 ± 1069 ± 10.491
 Heart rate (beats/min)70 ± 1271 ± 1373 ± 671 ± 1060 ± 40.15
Inflammatory marker
 C-reactive protein (mg/l)1.9 (0.9–4.2)2.3 (1.0–5.1)1.6 (0.6–3.7)1.4 (0.9–3.6)1.4 (0.6–5.7)0.436
Lipid panel
 Total cholesterol (mg/dl)164 ± 38168 ± 34166 ± 41151 ± 48172 ± 200.318
 Triglyceride (mg/dl)120 ± 78112 ± 70186 ± 123113 ± 66144 ± 920.066
 HDL cholesterol (mg/dl)44 ± 1345 ± 1338 ± 1043 ± 1242 ± 130.521
 LDL cholesterol (mg/dl)97 ± 34103 ± 2991 ± 3685 ± 43104 ± 210.16
Clinical diagnosis
 Stable angina68 (72)41 (73)6 (75)19 (76)2 (40)0.454
 NSTACS26 (28)15 (27)2 (25)6 (24)3 (60)0.454
Artery studied0.153
 Left anterior descending75 (80)46 (82)5 (63)20 (80)4 (80)
 Left circumflex12 (13)6 (11)1 (12)5 (20)0
 Right coronary7 (7)4 (7)2 (25)01 (20)
Angiographic parameters
 Proximal location10 (11)6 (11)04 (16)00.766
 MLD (mm)1.83 ± 0.581.93 ± 0.611.59 ± 0.451.79 ± 0.551.44 ± 0.210.151
 Reference diameter (mm)2.62 ± 0.652.72 ± 0.722.36 ± 0.572.60 ± 0.552.14 ± 0.370.166
 Percentage diameter stenosis (%)30 ± 1229 ± 1232 ± 1531 ± 1232 ± 110.774
 Lesion length (mm)12 ± 712 ± 712 ± 712 ± 510 ± 50.928

Values are mean ± SD, n (%), or median (interquartile range).

CAD = coronary artery disease; CFR = coronary flow reserve; DBP = diastolic blood pressure; FFR = fractional flow reserve; HDL = high-density lipoprotein; LDL = low-density lipoprotein; MLD = minimal luminal diameter; NSTACS = non–ST-segment elevation acute coronary syndromes; PCI = percutaneous coronary intervention; SBP = systolic blood pressure.