Table 2

Summary of MACE Comparing KBI Versus No KBI in 1- and 2-Stent Technique Bifurcation Studies

Trial/First Author (Ref.#)Study DesignStent StrategyKBINon-KBIFollow-Up (Months)MACE KBI Versus Non-KBIp ValueTVR KBI Versus Non-KBIp Value
Provisional
 Thubesis (80)RCTCrossover5654623.2 vs. 24.1%NS17.9% vs. 14.8%NS
 Nordic III (31)RCTCrossover23823962.1% vs. 2.5%NS1.3% vs. 1.7%NS
 COBIS I (32)RegistryCrossover7363292210.0 vs. 4.9%%<0.059.1% vs. 3.4%%<0.05
 COBIS II (33)RegistryCrossover6201,28136 (IQR: 25–50)6.8% vs. 8.6%0.0485.8% vs. 6.6%NS
 Yamawaki et al. (81)RegistryCrossover1321243614.6% vs. 6.9%NS12.3% vs. 5.1%NS
 CORPAL Kiss (82)RCTCrossover124120129% vs. 6%NS4% vs. 1.7%NS
 SMART-STRATEGY (34)RCTCrossover1301283620.8% vs. 11.7%0.04916.2% vs. 10.9%NS
2-stent strategy
 Ge et al. (81)ObservationalCrush11665919.8% vs. 38.5%<0.059.5% vs. 24.6%<0.05
 Grundeken et al. (83)RegistryCulotte/Tryton62412112NDND4.7% vs. 2.9%<0.05

COBIS = Korean Coronary Bifurcation Stenting; CORPAL Kiss = Cordoba & Las Palmas Kiss; IQR = interquartile range; KBI = kissing balloon inflation; MACE = major adverse cardiac event(s); ND = not determined; NS = nonsignificant; RCT = randomized controlled trial; SMART-STRATEGY = Smart Angioplasty Research team-Optimal STRATEGY for Side Branch Intervention in Coronary Bifurcation Lesions; TVR = target vessel revascularization.