Table 1

Baseline Characteristics

Age, yrs55 ± 15
Male24 (48)
NYHA functional class III or IV45 (90)
Pre-syncope or syncope21 (42)
History of atrial fibrillation3 (6)
Permanent pacemaker7 (14)
Internal cardioverter-defibrillator8 (16)
Family history of HCM12 (24)
Family history of SCD3 (6)
Mitral regurgitation, moderate11 (22)
Maximum ventricular wall thickness, mm20.9 ± 5.1
Left ventricular ejection fraction, %69 ± 8
Maximum septal thickness, mm20.1 ± 5.1
Basal septal hypertrophy, %33 (66)
Prior septal reduction3 (6)
Medications
 Beta-receptor antagonist42 (84)
 Calcium-channel blocker24 (48)
 ACE inhibitor or ARB14 (28)
 Disopyramide6 (12)
 Amiodarone1 (2)

Values are mean ± SD or n (%).

ACE = angiotensin-converting enzyme; ARB = angiotensin-receptor blocker; HCM = hypertrophic cardiomyopathy; NYHA = New York Heart Association; SCD = sudden cardiac death.