Table 1

Patient Demographic and Clinical Characteristics

CharacteristicBMMC Group (n = 23)PBMC Group (n = 18)Control Group (n = 19)p Value
Age (yrs)55.2 ± 8.854.6 ± 11.054.2 ± 7.40.94
Male19 (83)14 (78)17 (90)0.63
Body mass index (kg/m2)26.0 ± 3.426.3 ± 4.326.4 ± 2.40.92
Risk factors for coronary artery disease
 Diabetes mellitus1 (4)0 (0)0 (0)0.44
 Hypertension10 (44)0 (0)8 (42)0.004
 Family history of coronary heart disease13 (57)6 (33)10 (53)0.30
 Hypercholesterolemia5 (22)2 (11)3 (16)0.66
 Current smoking10 (44)11 (61)11 (58)0.47
Angiography and infarct treatment
 Symptom onset to balloon (h)3.0 (2.5–4.1)3.5 (2.1–4.9)3.0 (2.1–3.9)0.71
 Infarct-related artery0.28
 Left anterior descending artery17 (74)10 (56)16 (84)
 Left circumflex artery2 (9)1 (6)1 (5)
 Right coronary artery4 (17)7 (39)2 (11)
TIMI flow grade after primary PCI0.03
 24 (17)0 (0)0 (0)
 319 (83)18 (100)19 (100)
Cardiovascular magnetic resonance imaging
 LV ejection fraction (%)44.1 ± 9.742.9 ± 7.941.3 ± 8.50.62
 LV end-diastolic volume (ml/m2)94.4 ± 13.595.3 ± 13.0100.4 ± 17.00.40
 LV end-systolic volume (ml/m2)53.3 ± 13.654.7 ± 12.059.3 ± 14.80.38
 Infarct mass (g/m2)14.5 ± 7.410.9 ± 4.614.1 ± 7.40.22
 Presence of microvascular obstruction15 (65)11 (61)13 (68)0.60
Cell infusion
 Days after primary PCI6 (4–7)5 (4–7)
 Number of injected cells (×106)291 ± 173288 ± 91
 Absolute number of CD34+ cells (×106)6.8 ± 5.10.3 ± 0.1
 Absolute number of CD14+ cells (×106)17.9 ± 9.463.5 ± 30.1
Medication at discharge
 Aspirin23 (100)18 (100)19 (100)
 Clopidogrel23 (100)18 (100)19 (100)
 Beta-blockers22 (96)18 (100)19 (100)0.44
 ACE inhibitor22 (96)14 (78)18 (95)0.12
 ATII-receptor blocker0 (0)1 (6)1 (5)0.53
 Nitrates0 (0)0 (0)0 (0)
 Calcium-channel antagonists0 (0)1 (6)1 (5)0.53
Medication at 4-month follow-up
 Aspirin23 (100)18 (100)18 (95)0.33
 Clopidogrel18 (78)16 (89)18 (95)0.28
 Beta-blockers19 (83)17 (94)19 (100)0.11
 ACE inhibitor20 (87)13 (72)18 (95)0.15
 ATII-receptor blocker2 (9)1 (6)2 (11)0.86
 Nitrates1 (4)0 (0)2 (11)0.34
 Calcium-channel antagonists0 (0)0 (0)1 (5)0.53

Values are mean ± SD, n (%), or median (25th to 75th percentile).

ACE = angiotensin-converting-enzyme; AT = angiotensin; BMMC = bone marrow mononuclear cell; LV = left ventricular; PBMC = peripheral blood mononuclear cell; PCI = percutaneous coronary intervention; TIMI = Thrombolysis In Myocardial Infarction.