Table 1

Baseline Characteristics

VariableHCMASp Value
Age, yrs55 ± 1572 ± 9<0.0001
Male24 (48)21 (42)0.40
Body mass index, kg/m233.6 ± 7.830.2 ± 5.40.01
NYHA functional class III or IV45 (90)19 (38)<0.0001
Pre-syncope or syncope21 (42)9 (18)0.02
History of hypertension32 (64)38 (76)0.30
LDL cholesterol, mg/dl104 ± 4497 ± 420.40
History of smoking26 (52)32 (64)0.20
History of atrial fibrillation3 (6)13 (26)0.01
Permanent pacemaker10 (20)8 (16)0.80
Internal cardioverter-defibrillator8 (16)1 (2)0.03
Family history of HCM12 (24)
Family history of SCD3 (6)
Prior septal reduction3 (6)
Etiology of valvular disease
 Calcific38 (76)
 Rheumatic4 (8)
 Radiation-induced4 (8)
 Bicuspid4 (8)
Echocardiographic findings
 Left ventricular ejection fraction, %69 ± 857 ± 17<0.0001
 Mitral regurgitation, moderate or greater11 (22)4 (8)0.09
 Maximum ventricular wall thickness, mm20.9 ± 5.112.5 ± 2.6<0.0001
 Basal septal hypertrophy, %33 (66)
 Aortic valve area by TVI, cm21.02 ± 0.21
 Corrected aortic valve MIG, mm Hg54 ± 16
 Mean AS gradient, mm Hg33 ± 10
Medications
 Beta-receptor antagonist42 (84)30 (60)0.01
 Calcium-channel blocker24 (48)5 (10)<0.0001
 ACE inhibitor or ARB14 (28)28 (56)0.008
 Disopyramide6 (12)0 (0)0.03
 Amiodarone1 (2)4 (8)0.40

Values are mean ± SD or n (%).

ACE = angiotensin-converting enzyme; ARB = angiotensin-receptor blocker; AS = aortic valvular stenosis; HCM = hypertrophic cardiomyopathy; LDL = low-density lipoprotein; MIG = maximal instantaneous gradient; NYHA = New York Heart Association; SCD = sudden cardiac death; TVI = tissue velocity imaging.