Author + information
- Received October 27, 2016
- Revision received November 14, 2016
- Accepted November 17, 2016
- Published online January 18, 2017.
- S1936879816320842-03903fdcfb1593e0e8033e0ef817f9fbHidehiro Kaneko, MD, PhD,
- S1936879816320842-610d4a497a21d2ed94f371a9cf7baa0fFrank Hoelschermann, MD,
- S1936879816320842-95592a41fe825018d0e6461313548ba4Grit Tambor, MD,
- S1936879816320842-9a548d1d5afff6ae3b3658232d053098Michael Neuss, MD and
- S1936879816320842-2292214f4446d00fb5af6191f5632831Christian Butter, MD∗ ()
- ↵∗Reprint requests and correspondence:
Dr. Christian Butter, Department of Cardiology, Heart Center Brandenburg, Department of Cardiology, Medical School Brandenburg, Ladeburger Strasse 17, Bernau D-16321, Germany.
A 74-year-old man was transferred to our institution due to severe aortic regurgitation (AR) (Figure 1A) and heart failure. Because of his background characteristics, including a prior pulmonary embolism, amputation of lower extremity due to squamous cell carcinoma, active methicillin-resistant Staphylococcus aureus infection, the patient was considered to be at high risk for conventional surgery. Hence, we decided to perform transcatheter aortic valve replacement (TAVR).
Multidetector computed tomography showed a large aortic annulus (annulus area of 677 mm2, annulus perimeter of 98.1 mm) with no calcification (Figure 1B). Therefore, we prepared the second transcatheter heart valve (THV) for rescue valve-in-valve procedure.
Transfemoral TAVR was performed under general anesthesia. A 29-mm Sapien 3 (Edwards Lifesciences, Irvine, California) was implanted with overfilling of the deployment balloon with 5.5 ml of additional volume (Figure 2A). Implanted THV remained in the aortic position for few seconds, then dislocated to the left ventricle (Figure 2B). He developed pulseless electrical activity and we immediately initiated cardiopulmonary resuscitation. We inflated the delivery balloon in the left ventricle (Figure 2C) and pulled up the THV to the aortic position. The THV was implanted again with overfilling of 10.0 ml of additional volume to overexpand THV maximally (Figure 2D). This time, THV stayed in the aortic position. However, significant AR remained due to the high implanted position and hemodynamics sustained unstable. Therefore, we immediately implanted the second 29-mm SAPIEN 3 with overfilling of 5.5 ml of additional volume (Figure 2E) lower than the first THV. After the implantation of the second THV, aortography showed minimal AR (Figure 2F) and the hemodynamic status stabilized. The subsequent post-operative course was uneventful, and the patient was discharged with no sequela on post-operative day 8.
TAVR for pure AR remains challenging, particularly for patients with large aortic annulus. As expected, the first THV dislocated into the left ventricle and resulted in hemodynamic collapse. However, we performed a rescue valve-in-valve procedure immediately, because this known complication was taken into consideration during planning. Because of the lack of calcification in the aortic annulus in pure AR, TAVR for pure AR is technically difficult. Therefore, we must undertake this procedure with the utmost preparation.
Drs. Kaneko and Hoelschermann contributed equally to this publication.
The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received October 27, 2016.
- Revision received November 14, 2016.
- Accepted November 17, 2016.
- American College of Cardiology Foundation