Author + information
- Received October 22, 2015
- Revision received December 17, 2015
- Accepted December 17, 2015
- Published online April 25, 2016.
- Sung Gyun Ahn, MD, PhDa,b,
- Olivia Y. Hung, MD, PhDb,
- Jun-Won Lee, MDa,
- Ji Hyun Lee, MDa,
- Young Jin Youn, MDa,
- Min-Soo Ahn, MDa,
- Jang-Young Kim, MD, PhDa,
- Byung-Su Yoo, MD, PhDa,
- Seung-Hwan Lee, MD, PhDa,
- Junghan Yoon, MD, PhDa,
- Woocheol Kwon, MD, PhDc,∗∗ ( and )
- Habib Samady, MDa,∗ ()
- aDivision of Cardiology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital, Wonju, Republic of Korea
- bDivision of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia
- cDepartment of Radiology, Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital, Wonju, Republic of Korea
Objectives The aim of this study was to investigate the predictive accuracy of invasive coronary microvascular indexes for identifying microvascular obstruction (MVO) on cardiac magnetic resonance imaging (CMR) in patients treated with primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI).
Background We hypothesized that a combination of the index of microcirculatory resistance (IMR) and the thermodilution-derived coronary flow reserve (CFRthermo) will enhance the predictive accuracy of detecting MVO compared with either index alone.
Methods The IMR and CFRthermo were measured using a single pressure sensor/thermistor-tipped guidewire in 40 STEMI patients immediately after PCI and related to MVO assessed by CMR day 7. The primary endpoint was the predictive accuracy of the IMR for detecting MVO.
Results Patients with an IMR >36 (upper tertile) had a higher rate of MVO compared with those with an IMR ≤36 (93% vs. 39%; p = 0.001). MVO occurred in all patients with an IMR >36 and a CFRthermo ≤1.7 and in no patients with an IMR ≤36 and a CFRthermo >1.7. The IMR remained an independent predictor of MVO (odds ratio: 1.212, 95% confidence interval [CI]: 1.004 to 1.464; p = 0.045) after adjustment for age, creatine kinase-myocardial band, myocardial blush grade, thrombus burden, and CFRthermo. Both the IMR (area under the curve, 0.868, 95% CI: 0.719 to 0.956; p = 0.001) and the CFRthermo (area under the curve, 0.706, 95% CI: 0.536 to 0.842; p = 0.03) were predictive of MVO. Combined IMR and CFRthermo increased the area under the curve for MVO to 0.941.
Conclusions In patients who underwent primary PCI for STEMI, an increased IMR has an independent predictive value for MVO detection, and combined high IMR and low CFRthermo are highly predictive of MVO. These indexes could be used to further risk-stratify patients and guide regional and systemic therapies.
Dr. Ahn has received support from the CardioVascular Research Foundation, Korea. Dr. Hung has received an NRSA training grant (5T32HL007745). Dr. Samady has received research funding from Volcano Corporation, St. Jude Medical, Medtronic, Inc., and Abbott Vascular. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Drs. Samady and Kwon contributed equally to this work.
- Received October 22, 2015.
- Revision received December 17, 2015.
- Accepted December 17, 2015.
- 2016 American College of Cardiology Foundation