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Peripheral arterial disease (PAD) is known to be associated with poor outcomes due to higher incidence of combined cardiovascular morbidity and mortality. We evaluated the clinical outcomes of hypertensive versus normotensive patients (pts) with PAD who underwent peripheral transluminal angioplasty (PTA).
The outcomes of 559 consecutive pts with symptomatic PAD who underwent PTA were enrolled for analysis. Pts were divided into two groups; PAD with hypertension (N=390) and PAD without hypertension (N=169). The incidence of restenosis, amputation rates and clinical outcomes were assessed at a follow-up of 1 year.
Hypertensive PAD pts had suffered from more diabetes mellitus (DM, 78.2% vs 64.5%; P=0.001), chronic kidney disease (CKD, 34.9% vs 13.0%; P<0.001), and need for dialysis (23.8% vs 8.9%; P<0.001). However, the incidence of wounds and claudication as the initial diagnosis for PAD were similar between the two groups. At 8 months follow-up, the incidence of binary restenosis, total occlusion of the limb were similar between the two groups. At 1-year follow up, the incidence of repeat PTA, amputation rate, and major adverse cardiovascular events (MACE) were similar between the two groups.
Although hypertensive PAD pts had higher comorbidity including DM and CKD, the incidence of restenosis and amputation rate, and MACE at 1 years following successful PTA were similar with those of PAD pts without hypertension.