Author + information
- S1936879815021469-700cf5cb00fe36da60d3e624b1bc5958Ji Young Park1,
- S1936879815021469-83e45353357d710a9dde9c5071cfa225Seung-Woon Rha2,
- S1936879815021469-38f9379288aee4a50a9131fa84c4a249Byoung Geol Choi2,
- S1936879815021469-5ad2c1999ed23ad295759ce26e3acbe8Se Yeon Choi2,
- S1936879815021469-53b75c6df57ff3836114113292e7ed5aSang Ho Park3 and
- S1936879815021469-e7fb692d66d88666def902b2ab5ef87fJi Yeon Hong4
Peripheral arterial disease (PAD) is known to be associated with poor outcomes. However, the impact of smoking on major clinical outcomes following percutaneous transluminal angioplasty (PTA) is not clear yet.
The 559 consecutive symptomatic PAD patients (pts) who underwent PTA were enrolled for this analysis. The incidence of restenosis, amputation rate and repeat revascularization were assessed between the current smoker (n=177) and non-smokers (n=382) in significant PAD (pts) who underwent PTA at 1 year.
Current smokers had more male gender (96.0% vs. 69.4%, p<0.01), whereas non-smokers had a higher incidence of hypertension (63.3% vs. 72.8%, p=0.029), diabetes mellitus (68.4% vs. 76.7%; P=0.039), cerebral vascular disease (11.3% vs. 20.2%, p=0.011), chronic kidney disease (22.0% vs. 31.2%; p=0.027), need for dialysis (11.9% vs. 22.8%; p=0.003), coronary artery disease (48.0% vs. 59.2%, p=0.017). Wounds as the initial diagnosis were higher in non-smoker group (55.9% vs. 68.6%, p=0.004), but ischemic resting pain as the initial diagnosis was highr in current smoker group (21.5% vs. 9.7% p<0.01) . PTA at iliac artery (36.2% vs. 20.2%, p<0.01), femoral artery (21.5% vs. 13.1%, p=0.017), and below the knee (60.5% vs. 72.8%, p=0.004) was more commonly performed in the current smokers. At 8 months, non-smokers had higher rate of total occlusion of the limb (35.1% vs. 50.8%, p=0.039). At 1-year, the incidence of repeat PTA, amputation rate, and major adverse cardiovascular events (MACE) were similar between the two groups.
Although current smokers had lower incidence of traditional cardiovascular risks, more frequently presented with critical limb ischemia and had higher rates of PTA compared with symptomatic PAD with non-smokers. Despite of expected worse outcomes in smokers, smoking itself did not negatively impacted on the 1-year incidence of repeat PTA and amputations rates following successful PTA.