Author + information
- S193687981502097X-59a4a9943380f3fa697938fae96ae3b8Morteza Safi1,
- S193687981502097X-4dbea8fc8ed87e9ab783b75db6bcabdeMohammad Hasan Namazi1,
- S193687981502097X-0edff00190a205b18980cddcdee40ec3Esfandiar Fooladi1,
- S193687981502097X-84e58dc0dbf090656d6ce86a4e388721Hossein Vakili1,
- S193687981502097X-b58da67a1bbcdbc35eeadcd8479bc820Saeed Alipour Parsa1,
- S193687981502097X-0942871c11d858a8f32488faf29ab64fIsa Khaheshi1,
- S193687981502097X-dd9686a61d8551c95966deb0f851e399Mohammad Amin Abbasi1 and
- S193687981502097X-1920953961d7031afaf7057f959b476cMohammad Reza Movahed Sr.2
The aim of this study was to investigate the efficacy and safety of intracoronary (IC) sodium nitroprusside infusion in comparison with IC adenosine for fractional flow reserve (FFR) measurement in moderate coronary artery lesions.
During a nine month period, consecutive of 98 patients with suspected or known coronary artery disease with moderate stenosis found during angiography (40 to 70% stenosis), were enrolled in this study. Hyperemia was induced by bolus doses of IC adenosine followed by sodium nitroprusside for FFR measurement.
Both IC adenosine and IC sodium nitroprusside induced similar and significant reduction in FFR. There was no statistically difference in FFR values between adenosine vs sodium nitroprsside infusions (mean FFR 84.3 ± 6.3 vs 85.7 ± 6.2, p= 0.1) respectively.
An IC bolus of sodium nitroprusside (100 μg) infusion induces a similar degree of hyperemia as IC bolus of 100-300 μg of adenosine. Therefore, IC sodium nitroprusside could be considered as an alternative drug to adenosine for FFR measurement with lower side effect profile.