Author + information
- Received June 27, 2016
- Revision received August 12, 2016
- Accepted September 8, 2016
- Published online December 12, 2016.
- Evan M. Zahn, MD∗ (, )
- Daniel Peck, MD,
- Alistair Phillips, MD,
- Phillip Nevin, RN,
- Kaylan Basaker, CVT,
- Charles Simmons, MD,
- Marion E. McRae, NP,
- Tracy Early, MA and
- Ruchira Garg, MD
- The Guerin Family Congenital Heart Program, The Heart Institute and Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, California
- ↵∗Reprint requests and correspondence:
Dr. Evan M. Zahn, The Heart Institute, 127 S. San Vicente Boulevard, AHSP-Suite A3600, Los Angeles, California 90048.
Objectives The goal of this study was to describe early and midterm outcomes of extremely premature newborns (EPNs) who underwent transcatheter echocardiographically guided patent ductus arteriosus (PDA) closure.
Background Surgical ligation of PDA in EPNs confers significant risk for procedural morbidity and adverse long-term outcomes.
Methods The Amplatzer Vascular Plug II was used in all cases. Post-ligation syndrome was defined using previously published parameters. Patients were followed at pre-specified intervals, and prospectively collected data were reviewed.
Results Transcatheter closure was attempted in 24 EPNs (mean procedural age 30 days [range 5 to 80 days], mean procedural weight 1,249 g [range 755 to 2,380 g]) and was successful in 88%. The 3 procedural failures were related to the development of left pulmonary artery (LPA) stenosis caused by the device, and all devices were removed uneventfully. Complications included 2 instances of device malposition, resolved with device repositioning, and 1 instance of LPA stenosis, requiring an LPA stent. There were no procedural deaths, cases of post-ligation syndrome, residual PDA, or device embolization. Survival to discharge was 96% (23 of 24), with a single late death unrelated to the procedure. After a median follow-up period of 11.1 months, all patients were alive and well, with no residual PDA or evidence of LPA or aortic coarctation.
Conclusions This newly described technique can be performed safely with a high success rate and minimal procedural morbidity in EPNs. Early and midterm follow-up is encouraging. Future efforts should be directed toward developing specific devices for this unique application.
This study was supported by a research grant from the Fashion Industries Guild. Dr. Zahn is a consultant and instructor for St. Jude Medical. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received June 27, 2016.
- Revision received August 12, 2016.
- Accepted September 8, 2016.
- 2016 American College of Cardiology Foundation