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Diabetes is a risk factor for cardiovascular disease. The goal of this study was to evaluate any association between aortic valve disease and diabetes using a very large database.
The Nationwide Inpatient Sample (NIS) database was utilized to perform statistical analysis to evaluate prevalence of aortic valve disease (ICD-9 code: 424.1 in diabetes vs non diabetes patient using two samples yeas 10 years apart in 1997 and 2007 in the United States.
A total of 1,410,132 patients with a diagnosis of diabetes were identified from year 2007 from a population of 8,043,415 inpatients admissions. The prevalence of aortic valve disease was 1.9 % in DM patients vs 1.1 in pt without DM, p<0.0001. Obesity increased over the years. In year 1997, a total of 912,466 patients were identified with DM from a total population of 7,148,420 inpatients admission. Prevalence of aortic valve disease was 1.7% in DM patients vs, 1% in patients without DM, p<0.0001.
Using a very large data base, we find significantly higher prevalence of aortic valve disease in DM patients. This suggests that DM has a negative effect on the aortic valve apparatus.