Author + information
Coronary no-reflow during primary PCI is a predictor of poorer cardiovascular outcome. Both endothelial dysfunction and no-reflow involves abnormal vascular function and hemostasis. Therefore, our aim was to assess the association between risk factors, endothelial dysfunction and no reflow during primary PCI.
Thirty consecutive patients with STEMI and normal flow during primary PCI were compared to 19 consecutive patients who had no reflow. All subjects underwent assessment of endothelial function (reactive hyperemia index- RHI) within 48-72 h post PCI using the EndoPAT device.
Age, sex, and frequency of hypertension were similar in both groups. Smokers were less likely to have no-reflow (Table). Post PCI there was less ST-segment resolution in the no-reflow group (48%+7 vs 81%+6; p=0.001). Patients who had no reflow had subsequently lower ejection fraction (39+10 vs 47+10; p=0.015). There was no difference in vascular function (RHI) between groups. (Figure)
Systemic vascular function is not associated with coronary no reflow.