Author + information
- Received April 14, 2015
- Revision received June 30, 2015
- Accepted August 17, 2015
- Published online December 28, 2015.
- Bernardo Cortese, MD∗∗ (, )
- Pedro Silva Orrego, MD∗,
- Pierfrancesco Agostoni, MD, PhD†,
- Dario Buccheri, MD∗,‡,
- Davide Piraino, MD∗,‡,
- Giuseppe Andolina, MD‡ and
- Romano Giuseppe Seregni, MD∗
- ∗Cardiac Department, A.O. Fatebenefratelli, Milano, Italy
- †Cardiac Department, University Medical Center Utrecht, Utrecht, the Netherlands
- ‡Cardiac Department, A.O.U.P. Paolo Giaccone, Palermo, Italy
- ↵∗Reprint requests and correspondence:
Dr. Bernardo Cortese, Interventional Cardiology, A.O. Fatebenefratelli Milano, Bastioni di Porta Nuova 21, 20100 Milano, Italy.
Objectives The authors sought to understand the clinical and angiographic outcomes of dissections left after drug-coated balloon (DCB) angioplasty.
Background Second-generation DCB may be an alternative to stents in selected populations for the treatment of native coronary lesions. However, the use of these devices may be hampered by a certain risk of acute vessel recoil or residual coronary dissection. Moreover, stenting after DCB has shown limited efficacy. Little is known about when a non–flow-limiting dissection is left after DCB angioplasty.
Methods This was a prospective observational study whose aim was to investigate the outcome of a consecutive series of patients with native coronary artery disease treated with second-generation DCB and residual coronary dissection at 2 Italian centers. We evaluated patient clinical conditions at 1 and 9 months, and angiographic follow up was undertaken at 6 months.
Results Between July 2012 and July 2014, 156 patients were treated with DCB for native coronary artery disease. Fifty-two patients had a final dissection, 4 of which underwent prosthesis implantation and 48 were left untreated and underwent angiographic follow-up after 201 days (interquartile range: 161 to 250 days). The dissections were all type A to C, and none determined an impaired distal flow. Complete vessel healing at angiography was observed in 45 patients (93.8%), whereas 3 patients had persistent but uncomplicated dissections, and 3 had binary restenosis (6.2%). Late lumen loss was 0.14 mm (−0.14 to 0.42). Major adverse cardiovascular events occurred in 11 patients in the entire cohort and in 4 of the dissection cohort (7.2% vs. 8.1%; p = 0.48). We observed 8 and 3 target lesion revascularizations, respectively (5.3% vs. 6.2%; p = 0.37).
Conclusions In this cohort of consecutive patients treated with new-generation DCB and left with a final dissection, this strategy of revascularization seemed associated with the sealing of most of dissections and without significant neointimal hyperplasia.
The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received April 14, 2015.
- Revision received June 30, 2015.
- Accepted August 17, 2015.
- 2015 American College of Cardiology Foundation