Author + information
- Received February 18, 2015
- Revision received May 5, 2015
- Accepted May 22, 2015
- Published online October 1, 2015.
- Giuseppe Santoro, MD∗ (, )
- Gianpiero Gaio, MD,
- Giovanbattista Capozzi, MD,
- Luca Giugno, MD,
- Maria Teresa Palladino, MD,
- Cristina Capogrosso, MD,
- Angelo Fabio D’Aiello, MD,
- Giuseppe Caianiello, MD and
- Maria Giovanna Russo, MD
- Paediatric Cardiology and Paediatric Cardiac Surgery, A.O.R.N. “Ospedali dei Colli,” 2nd University of Naples, Naples, Italy
- ↵∗Reprint requests and correspondence:
Dr. Giuseppe Santoro, Department of Cardiology, Ospedali dei Colli, II, Via Camillo Sorgente, 31, 84125 Salerno, Italy.
Objectives This study sought to evaluate the impact of arterial duct (AD) stenting in promoting catch-up growth of hypoplastic pulmonary artery (PA) tree in congenital heart disease with duct-dependent pulmonary circulation (CHD-DPC).
Background Significant and balanced PA growth following AD stenting has already been consistently reported in the literature. However, no data are so far available about the role of this approach in severe PA hypoplasia, which significantly impacts the risk of surgical repair.
Methods Pre-surgical angiographic PA evaluation was performed in 45 patients with confluent PAs submitted to neonatal AD stenting as palliation of CHD-DPC. PA growth was evaluated as Nakata Index and McGoon ratio as well as individual PA z-score changes, both in the whole population and according to the original vessel size (Nakata Index <100 mm2/m2, Group I [n = 15] vs. Nakata Index >100 mm2/m2, Group II [n = 30]).
Results Control angiography was performed 7.5 ± 6.5 months (median 6 months) after duct stenting, showing significant and balanced PA growth. The Nakata Index increased from 143 ± 73 mm2/m2 to 270 ± 88 mm2/m2 (124 ± 118%, p < 0.0001); left PA z-score from −0.7 ± 1.7 to 1.0 ± 1.4; right PA z-score from −0.6 ± 1.3 to 1.2 ± 1.3 (p < 0.0001 for both comparisons). Group I showed a greater increase of global PA growth (Nakata Index increase 227 ± 141% vs. 72 ± 57%, p < 0.001) as compared with Group II. Final PA size did not significantly differ between the groups (246 ± 105 mm2/m2 vs. 282 ± 78 mm2/m2, p = NS).
Conclusions Percutaneous AD stenting is highly effective in promoting a significant and balanced catch-up growth of diminutive PAs, being therefore advisable in this subset of patients as a reliable alternative to surgical palliation.
The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received February 18, 2015.
- Revision received May 5, 2015.
- Accepted May 22, 2015.
- 2015 American College of Cardiology Foundation