A Prospective, Single-Arm, Multicenter Trial of Ultrasound-Facilitated, Catheter-Directed, Low-Dose Fibrinolysis for Acute Massive and Submassive Pulmonary Embolism
The SEATTLE II Study
Gregory Piazza, Benjamin Hohlfelder, Michael R. Jaff, Kenneth Ouriel, Tod C. Engelhardt, Keith M. Sterling, Noah J. Jones, John C. Gurley, Rohit Bhatheja, Robert J. Kennedy, Nilesh Goswami, Kannan Natarajan, John Rundback, Immad R. Sadiq, Stephen K. Liu, Narinder Bhalla, M. Laiq Raja, Barry S. Weinstock, Jacob Cynamon, Fakhir F. Elmasri, Mark J. Garcia, Mark Kumar, Juan Ayerdi, Peter Soukas, William Kuo, Ping-Yu Liu, Samuel Z. Goldhaber and SEATTLE II Investigators
Ultrasound-Facilitated, Catheter-Directed, Low-Dose Fibrinolysis for Acute Massive and Submassive Pulmonary Embolism
A total of 150 patients with computed tomography (CT)-confirmed pulmonary embolism (PE), symptoms for 14 days or less, and a right ventricular (RV)/left ventricular (LV) diameter ratio of at least 0.9 underwent ultrasound-facilitated, catheter-directed, low-dose fibrinolysis according to a standardized protocol. Ultrasound-facilitated, catheter-directed, low-dose fibrinolysis for acute massive and submassive pulmonary embolism (PE) improved RV function, decreased pulmonary hypertension, and minimized intracranial hemorrhage. PA = pulmonary artery; tPA = tissue plasminogen.