Author + information
- Received August 19, 2013
- Accepted August 31, 2013
- Published online June 1, 2014.
- Yasunori Ueda, MD, PhD∗∗ (, )
- Koshi Matsuo, MD∗,
- Yuji Nishimoto, MD∗,
- Ryuta Sugihara, MD∗,
- Mayu Nishio, MD, PhD∗,
- Akio Hirata, MD, PhD∗,
- Mitsutoshi Asai, MD, PhD∗,
- Takayoshi Nemoto, MD∗,
- Ayaka Murakami, BS∗,
- Kazunori Kashiwase, MD, PhD∗,
- James E. Muller, MD† and
- Kazuhisa Kodama, MD, PhD∗
- ∗Cardiovascular Division, Osaka Police Hospital, Osaka, Japan
- †InfraReDx, Inc., Burlington, Massachusetts
- ↵∗Reprint requests and correspondence:
Dr. Yasunori Ueda, Cardiovascular Division, Osaka Police Hospital, 10-31 Kitayama-cho, Tennoji-ku, Osaka, 543-0035 Japan.
Angioscopy can detect vulnerable, lipid-rich coronary plaques (LRPs), but it requires removal of blood plus expert technique and interpretation (1,2). We studied the use of a near-infrared spectroscopy (NIRS) intravascular ultrasound (IVUS) catheter (3), which does not require blood removal, to detect LRP identified by angioscopy.
An angiogram (Fig. 1A) shows the mid-left anterior descending artery with a stent. Angioscopy shows a proximal, yellow LRP with a white fibrotic plaque under the stent. Through blood, NIRS detected the LRP (yellow halo on the IVUS image), and IVUS detected the stent. Throughout the artery, angioscopy (Fig. 1B, Online Video 1) detected yellow plaque at locations 2, 3, and 4, with white thrombus at 3. NIRS-IVUS (Fig. 1C, Online Video 2) and a chemogram (Fig. 1D) detected LRP (yellow) at locations 2, 3, and 4, with no LRP (red) at 1 and 5, coinciding with angioscopic findings.
The NIRS-IVUS catheter, which is easy to use and quantitative, might be a valuable tool to detect vulnerable plaques.
For accompanying videos, please see the online version of this paper.
Dr. Muller is the chief medical officer of InfraReDx; and has equity ownership in the company. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received August 19, 2013.
- Accepted August 31, 2013.
- American College of Cardiology Foundation