JACC: Cardiovascular Interventions
Acute Myocardial Infarction
CRT-107 Neutrophil to Lymphocyte Ratio Predicts Short Term Mortality (30 Days) in Patients Undergoing Primary Percutaneous Coronary Intervention Due to Acute ST Segment Elevation Myocardial Infarction
Ricardo Castillo, Olasumbo Awoniyi, Venkateswarlu Chintagumpala and Hal Chadow
Table1
| 1A.-Baseline Characteristics | ||||
|---|---|---|---|---|
| Variables | Population (n=240) | N/L < 3.5 (n=122) | N/L ≥ 3.5 (n=118) | P value |
| Mortality | 18 (7.5%) | 4 (3.3%) | 14 (11.9%) | 0.012 |
| Age in years (mean±SD) | 57.8 ± 12.8 | 57.22 ± 11.77 | 58.47 ± 13.90 | 0.455 |
| Gender: Men | 166 (69.2%) | 85 (69.7%) | 81 (68.6%) | 0.863 |
| Race: African American | 135 (56.3%) | 68 (55.7%) | 67 (56.8%) | 0.871 |
| History CAD | 59 (24.6%) | 29 (23.8%) | 30 (25.4%) | 0.766 |
| History hypertension | 171 (71.3%) | 89 (73%) | 82 (69.5%) | 0.554 |
| History Diabetes Mellitus | 92 (38.3%) | 42 (34.4%) | 50 (42.4%) | 0.651 |
| History Hyperlipidemia | 146 (60.8%) | 74 (60.7%) | 72 (61%) | 0.954 |
| History smoking | 114 (47.5%) | 60 (49.2%) | 54 (45.8%) | 0.596 |
| History LV systolic dysfunction | 86 (35.8%) | 39 (32%) | 47 (39.8%) | 0.204 |
| Renal dysfunction (GFR(MDRD) < 60 ml/hr) | 47 (19.6%) | 21 (17.2%) | 26 (22%) | 0.347 |
| Door to balloon time (minutes) (mean±SD) | 73.35 ± 35.83 | 72.07 ± 35.22 | 74.72 ± 36.57 | 0.568 |
| Hemoglobin (mean±SD) | 13.78 ± 1.99 | 13.90 ± 1.83 | 13.64 ± 2.16 | 0.318 |
| WBC (mean±SD) | 11.31 ± 5.01 | 10.58 ± 5.35 | 12.08 ± 4.52 | 0.021 |
| CPK (mean±SD) | 844.17 ± 2063.53 | 579.03 ± 1293.68 | 1123.28 ± 2620.00 | 0.047 |
| Creatinine (mean±SD) | 1.15 ± 0.74* | 1.12 ± 0.59 | 1.18 ± 0.87 | 0.537 |
| Troponin I (mean±SD) | 6.02 ± 20.36 α | 2.85 ± 11.77 | 9.37 ± 26.24 | 0.016 |
| 1B.-Univariate logistic regression, predictors of all-cause mortality at 30 days | ||
|---|---|---|
| Variable | P value | Odds Ratio (95% C.I.) |
| Age in years (mean±SD) | 0.142 | 1.028(0.991-1.066) |
| History LV systolic dysfunction | 0.026 | 3.080(1.147-8.269) |
| Door to balloon time (minutes) (mean±SD) | 0.032 | 1.010(1.001-1.019) |
| Hemoglobin (mean±SD) | 0.048 | 0.801(0.643-0.998) |
| WBC (mean±SD) | 0.011 | 1.109(1.024-1.200) |
| CPK (mean±SD) | 0.105 | 1.000(1.000-1.000) |
| Creatinine (mean±SD) | 0.028 | 1.584(1.052-2.385) |
| Troponin I (mean±SD) | 0.072 | 1.014(0.999-1.029) |
| N/L | 0.001 | 1.196(1.076-1.330) |
| 1C.-Multivariate logistic regression, predictors of all-cause mortality at 30 days | |||
|---|---|---|---|
| Variable | Odds ratio | 95% CI | p value |
| History LV systolic dysfunction | 4.468 | 1.240 - 16.102 | 0.022 |
| WBC | 1.095 | 1.014 - 1.182 | 0.021 |
| N/L ratio | 1.174 | 1.050 - 1.313 | 0.005 |
Abbreviations: CAD=coronary artery disease; LV=Left ventricle; GFR (MDRD)=glomerular filtration rate (Modification of Diet in Renal Disease); WBC=with blood cell count; CPK=creatine phospokinase; N/L=neutrophil to lymphocyte ratio. * Total population (n) =134, α total population (n) =237.
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