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Chronic kidney disease (CKD) is highly prevalent with significant morbidity and mortality rates among patients with coronary artery disease (CAD). The SYNTAX Score (Synergy Between Percutaneous Coronary Intervention With TAXUS and Cardiac Surgery) predicts the outcomes of patients undergoing percutaneous coronary intervention. Our aim was to evaluate the correlation between CKD and severity of coronary artery stenosis by calculating SYNTAX Score in non diabetic CKD patients.
SYNTAX Score was calculated for 180 non diabetic patients with CKD scheduled for coronary angiography. Serum creatinine and 24 hour proteinuria prior to invasive coronary angiography (ICA) were assessed in all patients. Patients were divided into 2 groups according to their estimated glomelular filtration rate, (group 1 with eGFR ≥15 to < 30 ml/min per 1.73 m2) and (group 2 with eGFR ≥ 30 ml/min per 1.73 m2).
coronary arteries lesions complexity increased progressively with decreasing kidney function as there were significant negative correlation between e-GFR and SYNTAX Score (r = -0.5, P = 0.0004) and significant positive correlation between 24 hr proteinuria and SYNTAX Score (r = 0.6, p = 0.0001). A multivariate regression analysis was performed for the predictors of the SYNTAX Score, including age and e-GFR. In this analysis, e-GFR (ß =-0.098, p = 0.01) and age (ß = 0.35, p = 0.001) were both independent predictors of higher Syntax Score
Serum creatinine, estimated glomerular filtration rate and 24 hours proteinuria were predictors of higher SYNTAX Score.