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Bariatric surgery proposed for treatment of obesity is often related with different types of complications and side effects.
Ghrelin, a recently discovered neuropeptide which is predominantly produced in the gastric fundus, is the only known hormone stimulating food intake (orexigenic hormone). Catheter-directed left Gastric Artery Chemical Embolization (GACE) performed in animal models showed to decrease blood ghrelin levels and lead to weight loss.
Here we provide our preliminary results of the First-In-Man study of Left Gastric Artery Embolization (GAE) safety and efficacy in obese patients.
5 patients with different degrees of obesity underwent left GAE with BeadBlock Embolic Bead 300–500μm microspheres (Biocompatibles UK Limited, Chapman House, Farnham Business Park, Weydon Lane Farnham, Surrey, GU9 8QL, UK).
Gastroscopy was performed in all patients before and after GAE and at 1 week follow up to rule out significant initial gastritis or ulcer and any worsening after the procedure. Blood Ghrelin level was also measured before the procedure as well as at 1, 2, 3 and 4 weeks follow up.
Observation on Ghrelin levels and patients' weight is planned at 3, 6 and 12 month follow up.
There was no case of periprocedural complications. 3 of 5 patients complained about slight pain in epigastrium after embolization during first few hours after the embolization, but control gogastroscopy did not reveal any impairments.
All patients reported significantly decreased appetite in first days after procedure.
Weight loss was observed in all patients at 1 month follow up: mean initial weight - 128.12±24.4kg was decreased to 114.86±21.3kg and mean initial Body Mass Index (BMI) - 42.26±6.8 was decreased to 37.86±5.7.
Early follow-up has demonstrated that GAE is safe and feasible. It may become a less invasive and effective method for treatment of obesity.
Further controlled studies enrolling larger number of patients is underway performed to confirm these initial findings.
- 2013 American College of Cardiology Foundation