Author + information
- Received December 18, 2012
- Revision received May 17, 2013
- Accepted June 6, 2013
- Published online November 1, 2013.
- Kari Kervinen, MD∗∗ (, )
- Matti Niemelä, MD∗,
- Hannu Romppanen, MD∗,†,
- Andrejs Erglis, MD‡,
- Indulis Kumsars, MD‡,
- Michael Maeng, MD§,
- Niels R. Holm, MD§,
- Jens F. Lassen, MD§,
- Pål Gunnes, MD‖,
- Sindre Stavnes, MD‖,
- Jan S. Jensen, MD¶,
- Anders Galløe, MD¶,
- Inga Narbute, MD‡,
- Dace Sondore, MD‡,
- Evald H. Christiansen, MD§,
- Jan Ravkilde, MD§,
- Terje K. Steigen, MD#,
- Jan Mannsverk, MD#,
- Per Thayssen, MD∗∗,
- Knud Nørregaard Hansen, MD∗∗,††,
- Steffen Helqvist, MD‡‡,
- Saila Vikman, MD§§,
- Rune Wiseth, MD‖‖,
- Jens Aarøe, MD¶¶,
- Jari Jokelainen, MSc##∗∗∗,
- Leif Thuesen, MD§,
- Nordic PCI Study Group
- ∗Division of Cardiology, Department of Medicine, Oulu University Hospital, Oulu, Finland
- †Kuopio University Hospital–Heart Center, Kuopio, Finland
- ‡Department of Cardiology, Paul Stradins Clinical Hospital, Riga, Latvia
- §Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark
- ‖Department of Cardiology, The Feiring Clinic, Feiring, Norway
- ¶Department of Cardiology, Gentofte University Hospital, Gentofte, Denmark
- #Department of Cardiology, University Hospital of North Norway, Tromsø, Norway
- ∗∗Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway
- ††Department of Cardiology, Odense University Hospital, Odense, Denmark
- ‡‡Department of Cardiology, Rigshospitalet, Copenhagen, Denmark
- §§Heart Center, Tampere University Hospital, Tampere University, Tampere, Finland
- ‖‖Department of Cardiology, St. Olav Hospital, Trondheim, Norway
- ¶¶Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark
- ##Institute of Health Sciences, University of Oulu, Oulu, Finland
- ∗∗∗Unit of General Practice, Oulu University Hospital, Oulu, Finland
- ↵∗Reprint requests and correspondence:
Dr. Kari Kervinen, Division of Cardiology, Department of Medicine, Oulu University Hospital, Oulu 90029, Finland.
Objectives The aim of the study was to compare long-term follow-up results of crush versus culotte stent techniques in coronary bifurcation lesions.
Background The randomized Nordic Stent Technique Study showed similar 6-month clinical and 8-month angiographic results with the crush and culotte stent techniques of de novo coronary artery bifurcation lesions using sirolimus-eluting stents. Here, we report the 36-month efficacy and safety of the Nordic Stent Technique Study.
Methods A total of 424 patients with a bifurcation lesion were randomized to stenting of both main vessel and side branch with the crush or the culotte technique and followed for 36 months. Major adverse cardiac events—the composite of cardiac death, myocardial infarction, stent thrombosis, or target vessel revascularization—were the primary endpoint.
Results Follow-up was complete for all patients. At 36 months, the rates of the primary endpoint were 20.6% versus 16.7% (p = 0.32), index lesion restenosis 11.5% versus 6.5% (p = 0.09), and definite stent thrombosis 1.4% versus 4.7% (p = 0.09) in the crush and the culotte groups, respectively.
Conclusions At 36-month follow-up, the clinical outcomes were similar for patients with coronary bifurcation lesions treated with the culotte or the crush stent technique. (Nordic Bifurcation Study. How to Use Drug Eluting Stents [DES] in Bifurcation Lesions? NCT00376571)
The study was supported by an unrestricted grant from the Cordis/Johnson & Johnson Company. Dr. Holm has received research grants and honoraria from Cordis Corp.; research grants, speaking fees, and honoraria from St. Jude Medical; speaking fees and honoraria from Terumo; and research grants from Medtronic. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. The authors have full access to the data of the study and take full responsibility for its integrity.
- Received December 18, 2012.
- Revision received May 17, 2013.
- Accepted June 6, 2013.
- American College of Cardiology Foundation