|First Author (Ref. #)||N||FU (Months)||Outcome||IVUS Criterion for Significance||Comment|
|Abizaid et al. (36)||122||12||MACE||MLD||No specific cutoff suggested. LMCA MLD >3 mm portends incremental risk, also determined by comorbidities and coronary artery disease in other territories|
|Ricciardi et al. (37)||107||29||MACE||MLA||No specific cutoff suggested. MLA was a predictor of cardiac events|
|Legutko et al.⁎||44||44||Ischemia||MLD, MLA||MLA <8 mm2 and MLD <2.8 mm correlated with FFR ≤0.75 and ischemia on 99Tc-Mibi-Spect|
|Jasti et al. (24)||51||11||Ischemia||MLD, MLA||MLA ≤5.9 mm2 and MLD ≤2.8 mm. FFR of ≤0.75 used as gold-standard reference|
|Fassa et al. (39)||214||40||MACE||MLA||MLA <7.5 mm2|
|de la Torre Hernandez et al. (40)||354||24||MACE||MLA||MLA <6 mm2|
|Kang et al. (38)||55||NA||Functional||FFR||IVUS-derived MLA of <4.8 mm2 correlated with FFR <0.80|
IVUS = intravascular ultrasound; LMCA = left main coronary artery; MACE = major adverse cardiovascular events; MLA = minimum lumen area; MLD = minimum lumen diameter; other abbreviations as in Table 1.
↵⁎ Legutko J, Dudek D, Rzeszutko L, Hubalewska A, Wizimirski M, Dubiel J. Invasive assessment of the borderline left main coronary artery stenosis—comparison with 99Tc-MIBI SPECT. Eur Heart J 2004;25:429(P2425).