Author + information
- Received April 19, 2011
- Revision received September 22, 2011
- Accepted November 21, 2011
- Published online April 1, 2012.
- Lakshmana K. Pendyala, MD⁎,
- Daisuke Matsumoto, MD, PhD⁎,
- Toshiro Shinke, MD, PhD⁎,
- Taizo Iwasaki, PhD†,
- Ryota Sugimoto, MEng†,
- Dongming Hou, MD, PhD⁎,
- Jack P. Chen, MD⁎,‡,
- Jaipal Singh, PhD⁎,
- Spencer B. King III, MD⁎,‡,
- Nicolas Chronos, MD⁎,‡ and
- Jinsheng Li, MD, PhD⁎,⁎ ()
- ↵⁎Reprint requests and correspondence:
Dr. Jinsheng Li, Saint Joseph's Translational Research Institute/Saint Joseph's Hospital of Atlanta, 380-B Northyards Boulevard, Atlanta, Georgia 30313
Objectives The current study sought to examine inflammation at the stented segments of Nobori (Terumo Corporation, Tokyo, Japan) and Cypher (Cordis, Miami, Florida) drug-eluting stents (DES), as well as free radical production and endothelial function of the adjacent nonstented segments in a pig coronary model.
Background Nobori is a novel DES, incorporating a biolimus A9-eluting biodegradable polymer coated only on the abluminal surface of the stent. These unique features may favorably affect inflammation and endothelial function, as compared to the currently marketed DES. Presently, pre-clinical data on direct comparison of the various generations of DES are not available.
Methods A total of 18 DES were implanted in pig coronary arteries and subsequently explanted at 1 month. Stented segments were assessed by angiography and histology. Ex vivo vasomotor function and superoxide production in segments proximal and distal to the stent were determined. The vasoconstriction, endothelial-dependent relaxation, and endothelial-independent relaxation of proximal and distal nonstented segments were measured.
Results Histological evaluation revealed lower inflammatory response with Nobori than with Cypher DES. There is trend for lower angiographic percentage diameter stenosis in Nobori versus Cypher groups (p = 0.054). There was increased endothelium-dependent relaxation, decreased endothelin-1–mediated contraction, and less superoxide production in the vessel segments proximal and distal to Nobori versus Cypher stents.
Conclusions Our data show significantly lower inflammatory response in the stented segments, and rapid recovery of endothelial function of peristent segments in the Nobori group compared with Cypher DES group at 1 month in porcine coronary artery model.
Dr. Iwasaki and Mr. Sugimoto are full-time employees of Terumo Corporation. Dr. Hou is a full-time employee of Boston Scientific Corporation. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Robert S. Schwartz, MD, served as Guest Editor for this paper.
- Received April 19, 2011.
- Revision received September 22, 2011.
- Accepted November 21, 2011.
- American College of Cardiology Foundation