Author + information
- Received September 14, 2011
- Revision received January 9, 2012
- Accepted January 18, 2012
- Published online March 1, 2012.
- Fabio Mangiacapra, MD⁎,†,⁎ (, )
- Giuseppe Patti, MD⁎,
- Emanuele Barbato, MD, PhD†,
- Aaron J. Peace, MD, PhD†,
- Elisabetta Ricottini, MD⁎,
- Vincenzo Vizzi, MD⁎,
- Laura Gatto, MD⁎,
- Andrea D'Ambrosio, MD⁎,
- Bernard De Bruyne, MD, PhD†,
- William Wijns, MD, PhD† and
- Germano Di Sciascio, MD⁎,⁎ ()
- ↵⁎Reprint requests and correspondence:
Dr. Fabio Mangiacapra or Prof. Germano Di Sciascio, Department of Cardiovascular Sciences, Campus Bio-Medico University, Via Álvaro del Portillo, 200, 00128 Rome, Italy
Objectives This study sought to validate the ability of the VerifyNow P2Y12 assay (Accumetrics, San Diego, California) in predicting both ischemic and bleeding events after elective percutaneous coronary intervention (PCI).
Background High and low levels of platelet reactivity are associated with ischemic and bleeding events, respectively, after PCI.
Methods A total of 732 patients on dual antiplatelet therapy undergoing elective PCI were recruited. Platelet reactivity was measured before PCI. The primary endpoint was the 30-day incidence of net adverse clinical events (NACE), defined as the occurrence of ischemic or bleeding events, in relation to P2Y12 reaction unit (PRU) distribution.
Results At receiver-operating characteristic curve analysis, PRU values could significantly discriminate between patients with and without bleeding events (area under the curve [AUC]: 0.72; 95% confidence interval [CI]: 0.65 to 0.80; p < 0.0001) and those with and without ischemic events (AUC: 0.68; 95% CI: 0.61 to 0.76; p < 0.0001). The optimal cutoffs for bleeding (PRU ≤178) and ischemic events (PRU ≥239) were used to define 3 groups: low platelet reactivity (LPR) (LPR = PRU ≤178), normal platelet reactivity (NPR) (NPR = PRU 179 to 238), and high platelet reactivity (HPR) (HPR = PRU ≥239). The incidence of NACE was 14.1% in the LPR group, 7.8% in the NPR group (p = 0.025 vs. LPR group), and 15.4% in the HPR group (p = 0.005 vs. NPR group). At multivariate analysis, PRU values in the NPR group were an independent predictor of reduced risk of 30-day NACE (odds ratio: 0.47, 95% CI: 0.27 to 0.81).
Conclusions A therapeutic window for platelet reactivity measured with the VerifyNow P2Y12 assay can be identified using specific thresholds that define a group of patients at lower risk for both ischemic and bleeding events. Adjunctive measures may be beneficial in patients with higher or lower platelet reactivity in order to improve clinical outcomes after PCI.
The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received September 14, 2011.
- Revision received January 9, 2012.
- Accepted January 18, 2012.
- American College of Cardiology Foundation