Author + information
- Received May 12, 2010
- Revision received November 29, 2010
- Accepted December 9, 2010
- Published online March 1, 2011.
- Yoshinobu Onuma, MD,
- Joanna J. Wykrzykowska, MD,
- Scot Garg, MBChB,
- Pascal Vranckx, MD,
- Patrick W. Serruys, MD, PhD⁎ (, )
- ARTS I and II Investigators
- ↵⁎Reprint requests and correspondence:
Dr. Patrick W. Serruys, Thoraxcenter, Erasmus Medical Center, Department of Interventional Cardiology, Dr Molerwaterplein 40, Ba-583, 3015-GD, Rotterdam, the Netherlands
Objectives We compared the 5-year outcomes of diabetic patients with multivessel disease treated with sirolimus-eluting stents (SES), bare-metal stents (BMS), and coronary artery bypass graft surgery (CABG) enrolled in the ARTS (Arterial Revascularization Therapy Study) I and II studies.
Background Diabetes is an established risk factor for major adverse cardiac events after revascularization. Recent trials suggest that revascularization with drug-eluting stents has equivalent safety to CABG up to 2 years.
Methods The ARTS I and II studies included 367 diabetic patients (SES: 159, CABG: 96, and BMS: 112) compared with respect to 5-year clinical outcomes.
Results The rate of major adverse cardiovascular and cerebrovascular events was significantly higher in patients treated with BMS (BMS 53.6% vs. CABG 23.4% vs. SES 40.5%; log-rank, p < 0.01 for SES vs. BMS and SES vs. CABG). There was no significant difference in mortality among all 3 groups. There was, however, a statistically significant difference in the myocardial infarction rate between BMS and CABG arms (BMS 11.0%, CABG 5.2%, SES 4.8%, p = 0.04 for SES vs. BMS and p = 0.76 for SES vs. CABG). The rate of repeat revascularization was significantly lower in patients treated with CABG compared with SES (SES 33.2% vs. CABG 10.7%, p < 0.001). Revascularization rate of patients treated with SES at 5 years approached that of patients treated with BMS although remained significantly lower. This “catch-up” phenomenon was not apparent in the nondiabetic population.
Conclusions At 5-year follow-up, CABG has comparable safety and superior efficacy compared with BMS and SES in the treatment of diabetic patients with multivessel disease.
- bare-metal stent(s) (BMS)
- coronary artery bypass graft (CABG)
- drug-eluting stent(s) (DES)
- multivessel disease (MVD)
The authors have reported that they have no relationships to disclose.
Drs. Onuma and Wykrzykowska contributed equally to this work.
- Received May 12, 2010.
- Revision received November 29, 2010.
- Accepted December 9, 2010.
- American College of Cardiology Foundation