Reparative Effects of Allogeneic Mesenchymal Precursor Cells Delivered Transendocardially in Experimental Nonischemic Cardiomyopathy
Peter J. Psaltis, Angelo Carbone, Adam J. Nelson, Dennis H. Lau, Troy Jantzen, Jim Manavis, Kerry Williams, Silviu Itescu, Prashanthan Sanders, Stan Gronthos, Andrew C.W. Zannettino and Stephen G. Worthley
(A, B) Representative anteroposterior (A) and “bull's-eye” (B) projections of a linear local shortening map display the multisegmental distribution of injection sites (brown circles) (linear local shortening: purple: >11.5%, red: <9.3%). (C) There was no significant difference in the segmental location of injection sites between the 2 treatment groups. Results shown are mean ± SEM. (D) Intramyocardial delivery was followed by minor elevations of serum troponin-T in both cohorts, without significant intergroup difference. Whisker bars show median value (horizontal line), with 25th to 75th interquartile range (box) and minimum and maximum range (bars). A = anterior; L = lateral; LV = left ventricular; MPC = mesenchymal precursor cells; P = posterior; P-A = periapical; S = septal.