Author + information
- Received February 22, 2010
- Revision received June 24, 2010
- Accepted July 10, 2010
- Published online October 1, 2010.
- Stéphane Rinfret, MD, SM⁎,⁎ (, )
- Wendy Ann Kennedy, PhD†,
- Jean Lachaine, PhD‡,
- Anne Lemay, PhD§,
- Josep Rodés-Cabau, MD⁎,
- David J. Cohen, MD, MSc∥,
- Olivier Costerousse, PhD⁎ and
- Olivier F. Bertrand, MD, PhD⁎
- ↵⁎Reprint requests and correspondence:
Dr. Stéphane Rinfret, Interventional Cardiology Laboratories, Institut Universitaire de Cardiologie et de Pneumologie de Québec, affilié à l'Université Laval, 2725, Chemin Ste Foy, Quebec G1V 4G5, Canada
Objectives This study sought to estimate the economic impact of same-day home discharge compared with overnight hospitalization after transradial percutaneous coronary intervention (PCI).
Background Same-day home discharge after transradial PCI and a bolus-only abciximab regimen was found to be clinically noninferior to the abciximab standard therapy and overnight hospitalization in patients with various forms of acute coronary syndromes.
Methods In the EASY (Early Discharge After Transradial Stenting of Coronary Arteries) trial, 1,005 patients were randomized after a bolus of abciximab and uncomplicated transradial coronary stenting, either to same-day home discharge and no infusion (outpatient group) or to overnight hospitalization and 12-h abciximab infusion (overnight-stay group). We estimated post-PCI health care cost (in Canadian dollars) of trial subjects and short-term economic impact of same-day home discharge. As randomization was done after the procedure, outcomes were similar, and PCI resource use showed minimal and nonsignificant differences, a post-PCI cost-minimization analysis was conducted. Detailed per-patient information of health care resources used immediately after PCI up to 30 days was collected.
Results Mean post-PCI hospital stay was 8.9 h for outpatients versus 26.5 h for overnight-stay patients (p < 0.001). At 30-day follow-up, the mean cumulative medical cost per outpatient was $1,117 ± $1,554 versus $2,258 ± $1,328 for overnight-stay patients. The mean difference of $1,141 (95% confidence interval: $962 to $1,320) was mainly due to the extra night for overnight hospital stay.
Conclusions In a real-world setting, same-day home discharge after uncomplicated transradial PCI and a bolus-only abciximab regimen resulted in a 50% relative reduction in medical costs. Extension of this outpatient strategy would be welcomed by the hospitals and reimbursement systems in a context of increasing demand for health care cost reduction. (Early Discharge After Transradial Stenting of Coronary Arteries [EASY]; NCT00169819)
This study was supported by the Cardiovascular Health Network of the Fonds de la Recherche en Santé du Québec (FRSQ), Canada. Drs. Rinfret and Bertrand are research scholars from FRSQ. Dr. Rinfret is a consultant for Abbott Vascular. Dr. Lachaine has received research grants from Pfizer Canada, Abbott Canada, Shire, Lundeck Theratechnologies, and Novartis. Dr. Cohen has received grant support from Eli Lilly, Daiichi-Sankyo, AstraZeneca, and Boehringer Ingelheim. Dr. Bertrand has provided consulting services for Cordis. All other authors have reported that they have no relationships to disclose.
- Received February 22, 2010.
- Revision received June 24, 2010.
- Accepted July 10, 2010.
- American College of Cardiology Foundation