(A and B) High magnification (100×) microscopic images of H&E-stained overlapped sections from coronary segments implanted with PES and BMS. (C and D) High magnification (400×) microscopic images of H&E-stained sections of BMS segments exhibited well-healed, thick fibrocellular neointima, completely covered with endothelial or endothelial-like cells. Small amounts of inspissated thrombus and fibrin deposits were observed (C). In PES, drug effect was clearly apparent for all of the overlapping PES in the form of a mixture of para-strut fibrin, amorphous material, and red blood cell debris, as well as widespread inflammatory cell infiltration (several large round mononuclear cells, black arrows) into vessel wall and focal medial necrosis beneath the stent struts. (E and F) Scanning electron microscopy shows overlapped region for both BMS and PES at 1 month. In contrast to BMS (E), PES (F) displayed dramatically more inflammatory cell density on the luminal surface (bar indicates 40 μm). H&E = hematoxylin-eosin staining; other abbreviations as in Figure 1.