Author + information
- Received March 11, 2019
- Revision received May 22, 2019
- Accepted May 28, 2019
- Published online September 2, 2019.
- Marius Hornung, MDa,
- Stefan C. Bertog, MDa,
- Iris Grunwald, MDa,b,
- Kolja Sievert, MDa,
- Philipp Sudholt, MDc,
- Markus Reinartz, MDa,
- Laura Vaskelyte, MDa,
- Ilona Hofmann, MDa and
- Horst Sievert, MDa,b,∗ ()
- aCardioVascular Center Frankfurt, Sankt Katharinen Hospital, Frankfurt, Germany
- bFaculty of Medical Science, Anglia Ruskin University, Chelmsford, United Kingdom
- cDepartment of Radiology, Sankt Katharinen Hospital, Frankfurt, Germany
- ↵∗Address for correspondence:
Dr. Horst Sievert, CardioVascular Center Frankfurt CVC, Seckbacher Landstrasse 65, 60389 Frankfurt, Germany.
Objectives The aim of this study was to evaluate the technical and clinical success of acute stroke interventions performed in our interventional cardiology center.
Background Dedicated interventional stroke centers remain limited. Interventional cardiologists have established networks of catheterization laboratories and the necessary infrastructure to provide around the clock interventional therapy. These networks may also provide the currently lacking universal rapid access to prompt stroke intervention.
Methods Between July 2012 and July 2018, 70 consecutive patients underwent acute stroke intervention for large-vessel occlusions. Seventeen patients (24%) had tandem or multiple vessel occlusions. The majority (n = 63, 90%) were admitted via our local stroke unit, and 7 (10%) patients were transferred from other regional referral centers.
Results In 43 (61%) patients, systemic fibrinolytic therapy was started after baseline imaging. Mean time between symptom onset and arrival to the cath lab was 138 min; mean door-to-vascular access time was 64 min; mean time between cath lab activation and its operational readiness was 13 min. In all cases, access to supra-aortic vessels was achieved. Mean time between femoral arterial puncture and lesion crossing was 26 min. Stent implantation for extracranial stenosis or dissection was performed in 14 (20%) cases. Thrombectomy of intracranial occlusions was done with a stent retriever (n = 64, 91%) or an aspiration system (n = 14, 20%). In 20 (28%) cases, a combination of techniques was used. Recanalization was technically successful (Thrombolysis In Cerebral Infarction flow grade 2b or 3) in 65 (93%) patients. The 30-day mortality was 18% (n = 13). Favorable clinical outcome, defined as a modified Rankin Scale score of 0 to 2, was achieved in 61% at 3-month follow-up.
Conclusions Acute stroke interventions can be performed safely and with high technical and clinical success by experienced interventional cardiologists.
Dr. Grunwald is cofounder and shareholder for Brainomix Ltd. Oxford. Dr. Sievert has received study honoraria, travel expenses, and consulting fees from 4tech Cardio, Abbott, Ablative Solutions, Ancora Heart, Bavaria Medizin Technologie GmbH, Bioventrix, Boston Scientific, Carag, Celonova, Cibiem, Comed B.V., CVRx, Edwards, Endologix, Hangzhou Nuomao Medtech, Hemoteq, Lifetech, Maquet Getinge Group, Medtronic, Mitralign, Mokita, Occlutech, pfm Medical, Renal Guard, Rox Medical, Vascular Dynamics, Venus, and Vivasure Medical. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received March 11, 2019.
- Revision received May 22, 2019.
- Accepted May 28, 2019.
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