Author + information
- Anil Kumar K. Jonnalagadda1,
- Pavlos Texakalidis2,
- Stefanos Giannopoulos3,
- Ehrin J. Armstrong4 and
- Damianos G. Kokkinidis4
Carotid artery stenting (CAS) is a reliable alternative to carotid endarterectomy for carotid artery stenosis but can be associated with periprocedural adverse events. Our objective was to investigate whether the preoperative administration of statins before CAS can decrease perioperative and 30-day adverse events.
Materials & Methods
This study was performed according to the PRISMA and MOOSE guidelines and eligible studies were identified through a comprehensive search of PubMed, Scopus and Cochrane Central until August 19, 2017. A meta-analysis was conducted with the use of random effects model. I-square was used to assess for heterogeneity.
Eleven studies involving 4088 patients overall were included. Patients who received statins prior to CAS had a significantly lower risk for stroke (OR: 0.39; 95% CI: 0.27 - 0.57; I2=0%) and death (OR: 0.30; 95% CI: 0.09 - 0.95; I2=0%). Statin use was not associated with reduced risk of transient ischemic attack (TIA) or myocardial infarction (MI).
Statin therapy prior to CAS confers protection for perioperative stroke and death without decreasing TIA or MI rates. Additional randomized trials are needed to reach safer conclusions on this topic.