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Methamphetamine use continues to increase in the United States and remains one of the most commonly used illicit drugs worldwide. It has been linked to worse cardiovascular outcomes. We aimed to assess the association of methamphetamine abuse with stroke and sudden cardiac death using the National Inpatient Sample (NIS) Database.
We performed a population-based retrospective analysis of the NIS database (year 2014) using the ICD-9-CM codes 305.7x and 304.4x. Patients were divided into two groups – those who had a diagnosis of methamphetamine abuse or dependence and those who did not. Weighted univariate analysis by chi-square test and multivariate survey logistic regression analysis were performed to calculate odds ratios.
A total of 35,354,148 patients were included in the analysis, out of which 184,039 patients had a diagnosis of methamphetamine abuse or dependence. After multivariate analysis adjusting for various demographic factors and co-morbidities, there was a significant increase in the risk of stroke (OR: 1.19, 95% CI: 1.10-1.28; p<0.001) and sudden cardiac death (OR: 1.27, 95% CI: 1.12-1.44; p<0.001) in patients with methamphetamine abuse.
In our study we found increased risk of stroke and sudden cardiac death with methamphetamine use. With increasing use of methamphetamine nationwide, potential cardiovascular and cerebrovascular effects need to be further investigated.